PDB entry 6q2j

View 6q2j on RCSB PDB site
Description: cryo-em structure of extracellular dimeric complex of ret/gfral/gdf15
Deposited on 2019-08-08, released 2019-10-02
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: EM
Resolution: 4.1 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth/differentiation factor 15
    Species: Homo sapiens [TaxId:9606]
    Gene: GDF15, MIC1, PDF, PLAB, PTGFB
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Growth/differentiation factor 15
    Species: Homo sapiens [TaxId:9606]
    Gene: GDF15, MIC1, PDF, PLAB, PTGFB
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: GDNF family receptor alpha-like
    Species: Homo sapiens [TaxId:9606]
    Gene: GFRAL, C6orf144, UNQ9356/PRO34128
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: GDNF family receptor alpha-like
    Species: Homo sapiens [TaxId:9606]
    Gene: GFRAL, C6orf144, UNQ9356/PRO34128
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (0-End)
      • conflict (85)
  • Chain 'F':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (0-End)
      • conflict (85)
  • Heterogens: CA, NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6q2jA (A:)
mgsshhhhhhssglevlfqgphmarngdhcplgpgrccrlhtvrasledlgwadwvlspr
evqvtmcigacpsqfraanmhaqiktslhrlkpdtvpapccvpasynpmvliqktdtgvs
lqtyddllakdchci

    Sequence, based on observed residues (ATOM records):
    >6q2jA (A:)
dhcplgpgrccrlhtvrasledlgwadwvlsprevqvtmcigacpsqfraanmhaqikts
lhrlkpdtvpapccvpasynpmvliqktdtgvslqtyddllakdchci

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6q2jB (B:)
mgsshhhhhhssglevlfqgphmarngdhcplgpgrccrlhtvrasledlgwadwvlspr
evqvtmcigacpsqfraanmhaqiktslhrlkpdtvpapccvpasynpmvliqktdtgvs
lqtyddllakdchci

    Sequence, based on observed residues (ATOM records):
    >6q2jB (B:)
dhcplgpgrccrlhtvrasledlgwadwvlsprevqvtmcigacpsqfraanmhaqikts
lhrlkpdtvpapccvpasynpmvliqktdtgvslqtyddllakdchci

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6q2jC (C:)
qtnnctylreqclrdangckhawrvmedacndsdpgdpckmrnssycnlsiqylvesnfq
fkeclctddfyctvnkllgkkcinksdnvkedkfkwnlttrshhgfkgmwsclevaeacv
gdvvcnaqlasylkacsangnpcdlkqcqaairffyqnipfniaqmlafcdcaqsdipcq
qskealhsktcavnmvppptclsvirscqndelcrrhyrtfqskcwqrvtrkchedenci
stlskqdltcsgsddckaayidilgtvlqvqctcrtitqseeslckifqhmlhrkscfny
ptlsnvkgmalytrkhankitltgfhspfngevgthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2jC (C:)
wsclevaeacvgdvvcnaqlasylkacsangnpcdlkqcqaairffyqnipfniaqmlaf
cdcaqsdipcqqskealhsktcavnmvppptclsvirscqndelcrrhyrtfqskcwqrv
trkchedencistlskqdltcsgsddckaayidilgtvlqvqctcrtitqseeslckifq
hmlhrkscfn

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6q2jD (D:)
qtnnctylreqclrdangckhawrvmedacndsdpgdpckmrnssycnlsiqylvesnfq
fkeclctddfyctvnkllgkkcinksdnvkedkfkwnlttrshhgfkgmwsclevaeacv
gdvvcnaqlasylkacsangnpcdlkqcqaairffyqnipfniaqmlafcdcaqsdipcq
qskealhsktcavnmvppptclsvirscqndelcrrhyrtfqskcwqrvtrkchedenci
stlskqdltcsgsddckaayidilgtvlqvqctcrtitqseeslckifqhmlhrkscfny
ptlsnvkgmalytrkhankitltgfhspfngevgthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2jD (D:)
wsclevaeacvgdvvcnaqlasylkacsangnpcdlkqcqaairffyqnipfniaqmlaf
cdcaqsdipcqqskealhsktcavnmvppptclsvirscqndelcrrhyrtfqskcwqrv
trkchedencistlskqdltcsgsddckaayidilgtvlqvqctcrtitqseeslckifq
hmlhrkscfn

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6q2jE (E:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflsptslregecqwpgcarvyfs
ffntsfpacsslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrlle
geglpfrcapdslevstrwaldreqrekyelvavctvhagareevvmvpfpvtvydedds
aptfpagvdtasavvefkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqt
frvehwpnetsvqangsfvratvhdyrlvlnrnlsisenrtmqlavlvndsdfqgpgagv
lllhfnvsvlpvslhlpstyslsvsrrarrfaqigkvcvencqafsginvqyklhssgan
cstlgvvtsaedtsgilfvndtkalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsy
vaeeagcplscavskrrleceecgglgsptgrcewrqgdgkgitrnfstcspstktcpdg
hcdvvetqdinicpqdclrgsivgghepgeprgikagygtcncfpeeekcfcepediqdp
lcdelcrgthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2jE (E:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflspgecqwpgcarvyfsffnts
fpacsslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrllglpfrc
apdslevstrwaldreqrekyelvavctvhevvmvpfpvtvydeddsaptfpagvdtasa
vvefkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqtfrvehwpnetsvq
angsfvratvhdyrlvlnrnlsisenrtmqlavlvndsgvlllhfnvsvlpvslhlpsty
slsvsrrarrfaqigkvcvencqafsginvqyklhsscstlgvvtsaedtsgilfvndtk
alrrpkcaelhymvvatdqqtsrqaqaqllvtvegsyvaeeagcplscavskrrleceec
gglgsptgrcewrqgdgkgitrnfstcspstktcpdghcdvvetqdinicpqdclrgsiv
gghepgeprgikagygtcncfpeeekcfcep

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6q2jF (F:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflsptslregecqwpgcarvyfs
ffntsfpacsslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrlle
geglpfrcapdslevstrwaldreqrekyelvavctvhagareevvmvpfpvtvydedds
aptfpagvdtasavvefkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqt
frvehwpnetsvqangsfvratvhdyrlvlnrnlsisenrtmqlavlvndsdfqgpgagv
lllhfnvsvlpvslhlpstyslsvsrrarrfaqigkvcvencqafsginvqyklhssgan
cstlgvvtsaedtsgilfvndtkalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsy
vaeeagcplscavskrrleceecgglgsptgrcewrqgdgkgitrnfstcspstktcpdg
hcdvvetqdinicpqdclrgsivgghepgeprgikagygtcncfpeeekcfcepediqdp
lcdelcrgthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2jF (F:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflspgecqwpgcarvyfsffnts
fpacsslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrllglpfrc
apdslevstrwaldreqrekyelvavctvhevvmvpfpvtvydeddsaptfpagvdtasa
vvefkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqtfrvehwpnetsvq
angsfvratvhdyrlvlnrnlsisenrtmqlavlvndsgvlllhfnvsvlpvslhlpsty
slsvsrrarrfaqigkvcvencqafsginvqyklhsscstlgvvtsaedtsgilfvndtk
alrrpkcaelhymvvatdqqtsrqaqaqllvtvegsyvaeeagcplscavskrrleceec
gglgsptgrcewrqgdgkgitrnfstcspstktcpdghcdvvetqdinicpqdclrgsiv
gghepgeprgikagygtcncfpeeekcfcep