PDB entry 6q1p

View 6q1p on RCSB PDB site
Description: Glucocerebrosidase in complex with pharmacological chaperone norIMX8
Class: hydrolase/inhibitor
Keywords: pharmacological chaperone, Gaucher disease, glycosidase, inhibitor, pKa, HYDROLASE, HYDROLASE-INHIBITOR complex
Deposited on 2019-08-05, released 2020-08-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6q1pa1, d6q1pa2
  • Chain 'B':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6q1pb1, d6q1pb2
  • Heterogens: P8Y, EDO, SO4, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6q1pA (A:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

    Sequence, based on observed residues (ATOM records): (download) 
    >6q1pA (A:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldfpakatlgethrlfpntmlfaseacvfweqsvrlgswdrgmqysh
siitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlghfsk
fipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfletisp
gysihtylwhrq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6q1pB (B:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

    Sequence, based on observed residues (ATOM records): (download) 
    >6q1pB (B:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgweqsvrlgswdrgmqy
shsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlghf
skfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfleti
spgysihtylwhrq