PDB entry 6q0r

View 6q0r on RCSB PDB site
Description: Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39
Class: ligase
Keywords: Ubiquitin, homeostasis, targeted protein degradation, LIGASE
Deposited on 2019-08-02, released 2019-11-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: DNA damage-binding protein 1
  Species: Homo sapiens [TaxId:9606]
  Gene: DDB1, XAP1
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q16531 (28-End)
  • Uniprot Q16531 (Start-863)
• Chain 'B':
  Compound: DDB1- and CUL4-associated factor 15
  Species: Homo sapiens [TaxId:9606]
  Gene: DCAF15, C19orf72
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q66K64 (49-End)
• Chain 'C':
  Compound: DDB1- and CUL4-associated factor 15
  Species: Homo sapiens [TaxId:9606]
  Gene: DCAF15, C19orf72
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q66K64 (45-262)
• Chain 'D':
  Compound: RNA-binding protein 39
  Species: Homo sapiens [TaxId:9606]
  Gene: RBM39, HCC1, RNPC2
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q14498 (24-End)
    • expression tag (22-23)
  Domains in SCOPe 2.08: d6q0rd1, d6q0rd2
• Chain 'E':
  Compound: DET1- and DDB1-associated protein 1
  Species: Homo sapiens [TaxId:9606]
  Gene: DDA1, C19orf58, PCIA1
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9BW61
• Heterogens: O6M, OXM, ZN, HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  Sequence, based on SEQRES records: (download)
  

  >6q0rD (D:)
  mgsshhhhhhsavdenlyfqgggrmrlyvgslhfnitedmlrgifepfgriesiqlmmds
  etgrskgygfitfsdsecakkaleqlngfelagrpmkvghvtertda
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6q0rD (D:)
  grmrlyvgslhfnitedmlrgifepfgriesiqlmmdsetgrskgygfitfsdsecakka
  leqlngfelagrpmkvghvter
  

  
  
• Chain 'E':
  No sequence available.