PDB entry 6pze

View 6pze on RCSB PDB site
Description: Crystal structure of human NA-45 Fab in complex with neuraminidase Y169aH mutant from A/Shanghai/2/2013 (H7N9)
Class: immune system
Keywords: antibody, inhibition mechanism, IMMUNE SYSTEM
Deposited on 2019-07-31, released 2019-12-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuraminidase
    Species: Influenza A virus (A/Shanghai/02/2013(H7N9)) [TaxId:1332244]
    Database cross-references and differences (RAF-indexed):
    • Uniprot V9NZ28 (5-392)
      • engineered mutation (92)
    Domains in SCOPe 2.08: d6pzea_
  • Chain 'H':
    Compound: na-45 fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6PZE
    Domains in SCOPe 2.08: d6pzeh_
  • Chain 'L':
    Compound: na-45 fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6PZE
    Domains in SCOPe 2.08: d6pzel1, d6pzel2
  • Heterogens: BMA, CA, MAN, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pzeA (A:)
gspsrrnfnnltkglctinswhiygkdnavrigessdvlvtrepyvscdpdecrfyalsq
gttirgkhsngtihdrsqyraliswplsspptvhnsrvecigwsstschdgksrmsicis
gpnnnasavvwynrrpvaeintwarnilrtqesecvchngvcpvvftdgsatgpadtriy
yfkegkilkwesltgtakhieecscygertgitctcrdnwqgsnrpviqidpvamthtsq
yicspvltdnprpndpnigkcndpypgnnnngvkgfsyldgantwlgrtistasrsgyem
lkvpnaltddrskpiqgqtivlnadwsgysgsfmdywaegdcyracfyvelirgrpkedk
vwwtsnsivsmcssteflgqwnwpdgakieyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >6pzeA (A:)
rnfnnltkglctinswhiygkdnavrigessdvlvtrepyvscdpdecrfyalsqgttir
gkhsngtihdrsqyraliswplsspptvhnsrvecigwsstschdgksrmsicisgpnnn
asavvwynrrpvaeintwarnilrtqesecvchngvcpvvftdgsatgpadtriyyfkeg
kilkwesltgtakhieecscygertgitctcrdnwqgsnrpviqidpvamthtsqyicsp
vltdnprpndpnigkcndpypgnnnngvkgfsyldgantwlgrtistasrsgyemlkvpn
altddrskpiqgqtivlnadwsgysgsfmdywaegdcyracfyvelirgrpkedkvwwts
nsivsmcssteflgqwnwpdgakieyfl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6pzeH (H:)
dqvqlvesgpglvkpsetlsltctvsggsissssyywgwirqppgkglewigsiyysgst
yynpslksrvtisvdtsknqfslklssvtaadtavyycardpglewelsvlsnwfdpwgq
gtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkschhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6pzeH (H:)
vqlvesgpglvkpsetlsltctvsggsissssyywgwirqppgkglewigsiyysgstyy
npslksrvtisvdtsknqfslklssvtaadtavyycardpglewelsvlsnwfdpwgqgt
lvtvssastkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvep

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6pzeL (L:)
dqsvltqppsvsaapgqkvtiscsgsssnignnyvswyqqlpgtapklliydnnkrpsgi
pdrfsgsksgtsatlgitglqtgdeadyycgtwdtslsayvfatgtkvtvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6pzeL (L:)
svltqppsvsaapgqkvtiscsgsssnignnyvswyqqlpgtapklliydnnkrpsgipd
rfsgsksgtsatlgitglqtgdeadyycgtwdtslsayvfatgtkvtvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvap