PDB entry 6pyy

View 6pyy on RCSB PDB site
Description: crystal structure of human tryptophan 2,3-dioxygenase in complex with pf-06840003 in active site and exo site
Deposited on 2019-07-31, released 2020-01-01
The last revision was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO2, TDO
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO2, TDO
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO2, TDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48775 (Start-372)
      • expression tag (373-374)
  • Chain 'D':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO2, TDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48775 (Start-372)
      • expression tag (373-374)
  • Heterogens: HEM, H7S, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6pyyA (A:)
mlpvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiith
qayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmt
aldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllkse
qektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqvae
fqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslmd
idslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstyliprh
wipkmnptihkflehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6pyyA (A:)
ggliygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreif
qnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslq
frllenkigvlqnmrvpynrrhyrdnfkgeenelllkseqektllelveawlertpglep
hgfnfwgkleknitrgleeefiriqakeeseekeeqvaefqkqkevllslfdekrhehll
skgerrlsyralqgalmiyfyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlg
skagtggssgyhylrstvsdrykvfvdlfnlstyliprhwipkmnptihkf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6pyyB (B:)
mlpvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiith
qayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmt
aldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllkse
qektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqvae
fqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslmd
idslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstyliprh
wipkmnptihkflehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6pyyB (B:)
ggliygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreif
qnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslq
frllenkigvlqnmrvpynhyrdnfkgeenelllkseqektllelveawlertpglephg
fnfwgkleknitrgleeefiriqakeeseekeeqvaefqkqkevllslfdekrhehllsk
gerrlsyralqgalmiyfyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgsk
agtggssgyhylrstvsdrykvfvdlfnlstyliprhwipkm

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6pyyC (C:)
mlpvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiith
qayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmt
aldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllkse
qektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqvae
fqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslmd
idslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstyliprh
wipkmnptihkflehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6pyyC (C:)
gliygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifq
nghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqf
rllenkigvlqnmrvphyrdnfkgeenelllkseqektllelveawlertpglephgfnf
wgkleknitrgleevaefqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyr
eeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdry
kvfvdlfnlstyliprhwipkmnptihkfleh

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6pyyD (D:)
mlpvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiith
qayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmt
aldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllkse
qektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqvae
fqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslmd
idslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstyliprh
wipkmnptihkflehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6pyyD (D:)
gliygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifq
nghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqf
rllenkigvlqnmrvpynrrhyrdnfkgeenelllkseqektllelveawlertpgleph
gfnfwgkleknitrgleeefiriqakeeseekeeqvaefqkqkevllslfdekrhehlls
kgerrlsyralqgalmiyfyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgs
ksgyhylrstvsdrykvfvdlfnlstyliprhwipkmnptihkfleh