PDB entry 6pys

View 6pys on RCSB PDB site
Description: human pi3kalpha in complex with compound 2-10 ((3s)-3-benzyl-3-methyl- 5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3- dihydro-2h-indol-2-one)
Deposited on 2019-07-30, released 2019-08-28
The last revision was dated 2019-09-04, with a file datestamp of 2019-08-30.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CA
    Database cross-references and differences (RAF-indexed):
  • Heterogens: P5J, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6pysA (A:)
nreekilnreigfaigmpvcefdmvkdpevqdfrrnilnvckeavdlrdlnsphsramyv
yppnvesspelpkhiynkldkgqiivviwvivspnndkqkytlkinhdcvpeqviaeair
kktrsmllsseqlklcvleyqgkyilkvcgcdeyflekyplsqykyirscimlgrmpnlm
lmakeslysqlpmdcftmpsysrristatpymngetstkslwvinsalrikilcatyvnv
nirdidkiyvrtgiyhggeplcdnvntqrvpcsnprwnewlnydiyipdlpraarlclsi
csvkgrkgakeehcplawgninlfdytdtlvsgkmalnlwpvphgledllnpigvtgsnp
nketpclelefdwfssvvkfpdmsvieehanwsvsreagfsyshaglsnrlardnelren
dkeqlkaistrdplseiteqekdflwshrhycvtipeilpklllsvkwnsrdevaqmycl
vkdwppikpeqamelldcnypdpmvrgfavrclekyltddklsqyliqlvqvlkyeqyld
nllvrfllkkaltnqrighfffwhlksemhnktvsqrfglllesycracgmylkhlnrqv
eameklinltdilkqekkdetqkvqmkflveqmrrpdfmdalqgflsplnpahqlgnlrl
eecrimssakrplwlnwenpdimsellfqnneiifkngddlrqdmltlqiirimeniwqn
qgldlrmlpygclsigdcvglievvrnshtimqiqckgglkgalqfnshtlhqwlkdknk
geiydaaidlftrscagycvatfilgigdrhnsnimvkddgqlfhidfghfldhkkkkfg
ykrervpfvltqdfliviskgaqectktreferfqemcykaylairqhanlfinlfsmml
gsgmpelqsfddiayirktlaldkteqealeyfmkqmndahhggw

    Sequence, based on observed residues (ATOM records):
    >6pysA (A:)
nreekilnreigfaigmpvcefdmvkdpevqdfrrnilnvckeavdlrdlnsphsramyv
yppnvesspelpkhiynkldkgqiivviwvivsdkqkytlkinhdcvpeqviaeairkkt
rsmyqgkyilkvcgcdeyflekyplsqykyirscimlgrmpnlmlmakeslysqlpmdcf
tmpsysrtstkslwvinsalrikilcatyvnvnidkiyvrtgiyhggeplcdnvntqrvp
csnprwnewlnydiyipdlpraarlclsicsveehcplawgninlfdytdtlvsgkmaln
lwpvphgledllnpigvtgsnpnketpclelefdwfssvvkfpdmsvieehanwsvsrea
gfsyshaglsnrlardnelrendkeqlkaistrdplseiteqekdflwshrhycvtipei
lpklllsvkwnsrdevaqmyclvkdwppikpeqamelldcnypdpmvrgfavrclekylt
ddklsqyliqlvqvlkyeqyldnllvrfllkkaltnqrighfffwhlksemhnktvsqrf
glllesycracgmylkhlnrqveameklinltdilkqekkdetqkvqmkflveqmrrpdf
mdalqgflsplnpahqlgnlrleecrimssakrplwlnwenpdimsellfqnneiifkng
ddlrqdmltlqiirimeniwqnqgldlrmlpygclsigdcvglievvrnshtimqiqckn
shtlhqwlkdknkgeiydaaidlftrscagycvatfilgigdrhnsnimvkddgqlfhid
fghfldhrervpfvltqdfliviskgaqectktreferfqemcykaylairqhanlfinl
fsmmlgsgmpelqsfddiayirktlaldkteqealeyfmkqmndahhggw