PDB entry 6pyh

View 6pyh on RCSB PDB site
Description: cryo-em structure of full-length igf1r-igf1 complex. only the extracellular region of the complex is resolved.
Deposited on 2019-07-29, released 2019-10-23
The last revision was dated 2019-10-23, with a file datestamp of 2019-10-18.
Experiment type: EM
Resolution: 4.3 Å
R-factor: N/A
AEROSPACI score: 0.01 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: insulin-like growth factor 1 receptor
    Species: Mus musculus [TaxId:10090]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: insulin-like growth factor I
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1, IBP1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: insulin-like growth factor 1 receptor
    Species: Mus musculus [TaxId:10090]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6pyhA (A:)
eicgpgidirndyqqlkrlenctviegflhilliskaedyrsyrfpkltviteylllfrv
agleslgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlc
ylstidwslildavsnnyivgnkppkecgdlcpgtleekpmcekttinneynyrcwttnr
cqkmcpsvcgkractennecchpeclgschtpddnttcvacrhyyykgvcvpacppgtyr
fegwrcvdrdfcanipnaessdsdgfvihddecmqecpsgfirnstqsmycipcegpcpk
vcgdeekktktidsvtsaqmlqgctilkgnllinirrgnniaselenfmglievvtgyvk
irhshalvslsflknlrlilgeeqlegnysfyvldnqnlqqlwdwnhrnltvrsgkmyfa
fnpklcvseiyrmeevtgtkgrqskgdintrnngerascesdvlrftstttwknriiitw
hryrppdyrdlisftvyykeapfknvteydgqdacgsnswnmvdvdlppnkegepgillh
glkpwtqyavyvkavtltmvendhirgakseilyirtnasvpsipldvlsasnsssqliv
kwnpptlpngnlsyyivrwqrqpqdgylyrhnycskdkipirkyadgtidveevtenpkt
evcggdkgpccacpkteaekqaekeeaeyrkvfenflhnsifvprperrrrdvmqvantt
mssrsrnttvadtynitdpeefeteypffesrvdnkertvisnlrpftlyridihscnhe
aeklgcsasnfvfartmpaegaddipgpvtweprpensiflkwpepenpnglilmyeiky
gsqvedqrecvsrqeyrkyggaklnrlnpgnytariqatslsgngswtdpvffyvpaktt
yenfmhliialpvaillivgglvimlyvfhrkrnnsrlgngvlyasvnpeafsaadvyvp
dewevarekitmnrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmreriefln
easvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpeveqnnlvlipps
lskmiqmageiadgmaylnankfvhrnlaarncmvaedftvkigdfgmtrdiyetdyyrk
ggkgllpvrwmspeslkdgvftthsdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeg
glldkpdncpdmlfelmrmcwqynpkmrpsfleiigsikdemepsfqevsfyyseenkpp
epgtssglevlfq

    Sequence, based on observed residues (ATOM records):
    >6pyhA (A:)
eicgpgidirndyqqlkrlenctviegflhillisrsyrfpkltviteylllfrvagles
lgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlcylsti
dwslildavsnnyivgnkppkecgdlcpgtleecekttinneynyrcwttnrcqkmcpsv
cractennecchpeclgschpddnttcvacrhyyykgvcvpacppgtyrfegwrcvdrdf
canipsdgfvihddecmqecpsgfirnstqsmycipcegpcpkvcekktktidsvtsaqm
lqgctilkgnllinirrgnniaselenfmglievvtgyvkirhshalvslsflknlrlil
geeqlegnysfyvldnqnlqqlwdwnhrnltvrsgkmyfafnpklcvseiyrmeevtgtk
grqskgdintrnngerascesdvlrftstttwknriiitwhryrppdyrdlisftvyyke
apfknvteydgqdacgsnswnmvdvdlppnkegepgillhglkpwtqyavyvkavtltmv
endhirgakseilyirtnasvpsipldvlsasnsssqlivkwnpptlpngnlsyyivrwq
rqpqdcacpkteaekqaekeeaeyrkvfenflhnsifvprpypffesrvdnkertvisnl
rpftlyridihscnheaeklgcsasnfvfartmpaegaddipgpvtweprpensiflkwp
epenpnglilmyeikygsqvedqrecvsrqeyrkyggaklnrlnpgnytariqatslsgn
gswtdpvffyvpa

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6pyhB (B:)
gpetlcgaelvdalqfvcgdrgfyfnkptgygsssrrapqtgivdeccfrscdlrrlemy
caplkpaksa

    Sequence, based on observed residues (ATOM records):
    >6pyhB (B:)
tlcgaelvdalqfvcgdrgfyfnkptgygsssrrtgivdeccfrscdlrrlemycap

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6pyhD (D:)
eicgpgidirndyqqlkrlenctviegflhilliskaedyrsyrfpkltviteylllfrv
agleslgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlc
ylstidwslildavsnnyivgnkppkecgdlcpgtleekpmcekttinneynyrcwttnr
cqkmcpsvcgkractennecchpeclgschtpddnttcvacrhyyykgvcvpacppgtyr
fegwrcvdrdfcanipnaessdsdgfvihddecmqecpsgfirnstqsmycipcegpcpk
vcgdeekktktidsvtsaqmlqgctilkgnllinirrgnniaselenfmglievvtgyvk
irhshalvslsflknlrlilgeeqlegnysfyvldnqnlqqlwdwnhrnltvrsgkmyfa
fnpklcvseiyrmeevtgtkgrqskgdintrnngerascesdvlrftstttwknriiitw
hryrppdyrdlisftvyykeapfknvteydgqdacgsnswnmvdvdlppnkegepgillh
glkpwtqyavyvkavtltmvendhirgakseilyirtnasvpsipldvlsasnsssqliv
kwnpptlpngnlsyyivrwqrqpqdgylyrhnycskdkipirkyadgtidveevtenpkt
evcggdkgpccacpkteaekqaekeeaeyrkvfenflhnsifvprperrrrdvmqvantt
mssrsrnttvadtynitdpeefeteypffesrvdnkertvisnlrpftlyridihscnhe
aeklgcsasnfvfartmpaegaddipgpvtweprpensiflkwpepenpnglilmyeiky
gsqvedqrecvsrqeyrkyggaklnrlnpgnytariqatslsgngswtdpvffyvpaktt
yenfmhliialpvaillivgglvimlyvfhrkrnnsrlgngvlyasvnpeafsaadvyvp
dewevarekitmnrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmreriefln
easvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpeveqnnlvlipps
lskmiqmageiadgmaylnankfvhrnlaarncmvaedftvkigdfgmtrdiyetdyyrk
ggkgllpvrwmspeslkdgvftthsdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeg
glldkpdncpdmlfelmrmcwqynpkmrpsfleiigsikdemepsfqevsfyyseenkpp
epgtssglevlfq

    Sequence, based on observed residues (ATOM records):
    >6pyhD (D:)
eicgpgidirndyqqlkrlenctviegflhilliskaedyrsyrfpkltviteylllfrv
agleslgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlc
ylstidwslildavsnnyivgnkppkecgdlcpcekttinneynyrcwttnrcqkmcpsv
cactennecchpeclgschtpddnttcvacrhyyykgvcvpacppgtyrfegwrcvdrdf
canipnaesgfvihddecmqecpsgfirnstqsmycipcvcgdeekktktidsvtsaqml
qgctilkgnllinirrgnniaselenfmglievvtgyvkirhshalvslsflknlrlilg
eeqlegnysfyvldnqnlqqlwdwnhrnltvrsgkmyfafnpklcvseiyrmeevtgtkg
rqskgdintrnngerascesdvlrftstttwknriiitwhryrppdyrdlisftvyykea
pfknvteydcgsnswnmvdvdegepgillhglkpwtqyavyvkavtltndhirgakseil
yirtnasvpsipldvlsasnsssqlivkwnpptlpngnlsyyivrwqrqpqdgylyrhny
cskdkipirkyacacpkteaekqaekeeaeyrkvfenflhnsifvpypffesrvdnkert
visnlrpftlyridihscnheaeklgcsasnfvfartmpaegaddipgpvtweprpensi
flkwpepenpnglilmyeikygsqvedqrecvsrqeyrkyggaklnrlnpgnytariqat
slsgngswtdpvffyvpa