PDB entry 6py8

View 6py8 on RCSB PDB site
Description: crystal structure of the rbpj-notch1-nrarp ternary complex bound to dna
Deposited on 2019-07-29, released 2019-08-14
The last revision was dated 2020-02-26, with a file datestamp of 2020-02-21.
Experiment type: XRAY
Resolution: 3.75 Å
R-factor: N/A
AEROSPACI score: 0.06 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'B':
    Compound: Notch-regulated ankyrin repeat-containing protein
    Species: Homo sapiens [TaxId:9606]
    Gene: NRARP
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Recombining binding protein suppressor of hairless
    Species: Homo sapiens [TaxId:9606]
    Gene: RBPJ, IGKJRB, IGKJRB1, RBPJK, RBPSUH
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'E':
    Compound: Recombining binding protein suppressor of hairless
    Species: Homo sapiens [TaxId:9606]
    Gene: RBPJ, IGKJRB, IGKJRB1, RBPJK, RBPSUH
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Neurogenic locus notch homolog protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NOTCH1, TAN1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Notch-regulated ankyrin repeat-containing protein
    Species: Homo sapiens [TaxId:9606]
    Gene: NRARP
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Neurogenic locus notch homolog protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NOTCH1, TAN1
    Database cross-references and differences (RAF-indexed):
  • Chain 'X':
    Compound: DNA
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'Y':
    Compound: DNA
    Species: HOMO SAPIENS, synthetic [TaxId:9606]

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6py8B (B:)
    msqaelstcsapqtqrifqeavrkgntqelqsllqnmtncefnvnsfgpegqtalhqsvi
    dgnlelvkllvkfgadirlanrdgwsalhiaafgghqdivlylitkakyaasgr
    

    Sequence, based on observed residues (ATOM records):
    >6py8B (B:)
    qtqrifqeavrkgntqelqsllqnmtncefnvnsfgpegqtalhqsvidgnlelvkllvk
    fgadirlanrdgwsalhiaafgghqdivlylitka
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6py8C (C:)
    gerpppkrltreamrnylkergdqtvlilhakvaqksygnekrffcpppcvylmgsgwkk
    kkeqmerdgcseqesqpcafigignsdqemqqlnlegknyctaktlyisdsdkrkhfmls
    vkmfygnsddigvflskrikviskpskkkqslknadlciasgtkvalfnrlrsqtvstry
    lhveggnfhassqqwgaffihlldddesegeeftvrdgyihygqtvklvcsvtgmalprl
    iirkvdkqtalldaddpvsqlhkcafylkdtermylclsqeriiqfqatpcpkepnkemi
    ndgaswtiistdkaeytfyegmgpvlapvtpvpvveslqlngggdvamleltgqnftpnl
    rvwfgdveaetmyrcgesmlcvvpdisafregwrwvrqpvqvpvtlvrndgiiystsltf
    tytpepgprphcsaagailranss
    

    Sequence, based on observed residues (ATOM records):
    >6py8C (C:)
    rpppkrltreamrnylkergdqtvlilhakvaqksygnekrffcpppcvylmgsgwkkkk
    eqmerdgcseqesqpcafigignsdqemqqlnlegknyctaktlyisdsdkrkhfmlsvk
    mfygnsddigvflskrikviskpskkkqslknadlciasgtkvalfnrlrsqtvstrylh
    veggnfhassqqwgaffihlldddesegeeftvrdgyihygqtvklvcsvtgmalprlii
    rkvdkqtalldaddpvsqlhkcafylkdtermylclsqeriiqfqatpcpkepnkemind
    gaswtiistdkaeytfyegmgpvlapvtpvpvveslqlngggdvamleltgqnftpnlrv
    wfgdveaetmyrcgesmlcvvpdisafregwrwvrqpvqvpvtlvrndgiiystsltfty
    tpepgprph
    

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6py8E (E:)
    gerpppkrltreamrnylkergdqtvlilhakvaqksygnekrffcpppcvylmgsgwkk
    kkeqmerdgcseqesqpcafigignsdqemqqlnlegknyctaktlyisdsdkrkhfmls
    vkmfygnsddigvflskrikviskpskkkqslknadlciasgtkvalfnrlrsqtvstry
    lhveggnfhassqqwgaffihlldddesegeeftvrdgyihygqtvklvcsvtgmalprl
    iirkvdkqtalldaddpvsqlhkcafylkdtermylclsqeriiqfqatpcpkepnkemi
    ndgaswtiistdkaeytfyegmgpvlapvtpvpvveslqlngggdvamleltgqnftpnl
    rvwfgdveaetmyrcgesmlcvvpdisafregwrwvrqpvqvpvtlvrndgiiystsltf
    tytpepgprphcsaagailranss
    

    Sequence, based on observed residues (ATOM records):
    >6py8E (E:)
    rpppkrltreamrnylkergdqtvlilhakvaqksygnekrffcpppcvylmgsgwkkkk
    eqmerdgcseqesqpcafigignsdqemqqlnlegknyctaktlyisdsdkrkhfmlsvk
    mfygnsddigvflskrikviskpskkkqslknadlciasgtkvalfnrlrsqtvstrylh
    veggnfhassqqwgaffihlldddesegeeftvrdgyihygqtvklvcsvtgmalprlii
    rkvdkqtalldaddpvsqlhkcafylkdtermylclsqeriiqfqatpcpkepnkemind
    gaswtiistdkaeytfyegmgpvlapvtpvpvveslqlngggdvamleltgqnftpnlrv
    wfgdveaetmyrcgesmlcvvpdisafregwrwvrqpvqvpvtlvrndgiiystsltfty
    tpepgprphcs
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6py8F (F:)
    krrrqhgqlwfpegfkvseaskkkrreplgedsvglkplknasdgalmddnqnewgdedl
    etkkfrfeepvvlpdlddqtdhrqwtqqhldaadlrmsamaptppqgevdadcmdvnvrg
    pdgftplmiascsgggletgnseeeedapavisdfiyqgaslhnqtdrtgetalhlaary
    srsdaakrlleasadaniqdnmgrtplhaavsadaqgvfqilirnratdldarmhdgttp
    lilaarlavegmledlinshadvnavddlgksalhwaaavnnvdaavvllkngankdmqn
    nreetplflaaregsyetakvlldhfanrditdhmdrlprdiaqermhhdivrlldeynl
    vrspqlhga
    

    Sequence, based on observed residues (ATOM records):
    >6py8F (F:)
    krrrqhgqlwfpegfkvsevnvrgpdgftplmiascseedapavisdfiyqgaslhnqtd
    rtgetalhlaarysrsdaakrlleasadaniqdnmgrtplhaavsadaqgvfqilirnra
    tdldarmhdgttplilaarlavegmledlinshadvnavddlgksalhwaaavnnvdaav
    vllkngankdmqnnreetplflaaregsyetakvlldhfanrditdhmdrlprdiaqerm
    hhdivrlldeynlv
    

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6py8G (G:)
    msqaelstcsapqtqrifqeavrkgntqelqsllqnmtncefnvnsfgpegqtalhqsvi
    dgnlelvkllvkfgadirlanrdgwsalhiaafgghqdivlylitkakyaasgr
    

    Sequence, based on observed residues (ATOM records):
    >6py8G (G:)
    fqeavrkgntqelqsllqnvnsfgpegqtalhqsvidgnlelvkllvkfgadirlanrdg
    wsalhiaafgghqdivlylitkak
    

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6py8K (K:)
    krrrqhgqlwfpegfkvseaskkkrreplgedsvglkplknasdgalmddnqnewgdedl
    etkkfrfeepvvlpdlddqtdhrqwtqqhldaadlrmsamaptppqgevdadcmdvnvrg
    pdgftplmiascsgggletgnseeeedapavisdfiyqgaslhnqtdrtgetalhlaary
    srsdaakrlleasadaniqdnmgrtplhaavsadaqgvfqilirnratdldarmhdgttp
    lilaarlavegmledlinshadvnavddlgksalhwaaavnnvdaavvllkngankdmqn
    nreetplflaaregsyetakvlldhfanrditdhmdrlprdiaqermhhdivrlldeynl
    vrspqlhga
    

    Sequence, based on observed residues (ATOM records):
    >6py8K (K:)
    krrrqhgqlwfpegfkvsevnvrgpdgftplmiascsgseeeedapavisdfiyqgaslh
    nqtdrtgetalhlaarysrsdaakrlleasadaniqdnmgrtplhaavsadaqgvfqili
    rnratdldarmhdgttplilaarlavegmledlinshadvnavddlgksalhwaaavnnv
    daavvllkngankdmqnnreetplflaaregsyetakvlldhfanrditdhmdrlprdia
    qermhhdivrlldeynlv
    

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    No sequence available.