PDB entry 6pxw

View 6pxw on RCSB PDB site
Description: Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex.
Class: signaling protein/hormone
Keywords: insulin receptor, insulin, SIGNALING PROTEIN-HORMONE complex
Deposited on 2019-07-28, released 2019-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-09-04, with a file datestamp of 2019-08-30.
Experiment type: EM
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: INSR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6pxwa1, d6pxwa2, d6pxwa3, d6pxwa4
  • Chain 'B':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: INSR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6pxwb1, d6pxwb2, d6pxwb3, d6pxwb4
  • Chain 'C':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pxwA (A:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtakgktncpatvingqfve
rcwthshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvet
cpppyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnll
ctpclgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgl
ieeisgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnlt
itqgklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirt
sfdkillrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrs
ndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpld
pisvsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsrtwsp
pfesedsqkhnqseyedsageccscpktdsqilkeleessfrktfedylhnvvfvprpsr
krrslgdvgnvtvavptvaafpntsstsvptspeehrpfekvvnkeslvisglrhftgyr
ielqacnqdtpeercsvaayvsartmpeakaddivgpvtheifennvvhlmwqepkepng
livlyevsyrrygdeelhlcvsrkhfalergcrlrglspgnysvriratslagngswtep
tyfyvtdyldvpsniakiiigplifvflfsvvigsiylflrkrqpdgplgplyassnpef
ltasdvfpcsvyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktv
nesaslrerieflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslr
peaennpgrppptlqemiqmaaeiadgmaylnakkfvhrnlaarncmvahdftvkigdfg
mtrdiyetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqg
lsneqvlkfvmdggyldqpdncpervtdlmrmcwqfnpkmrptfleivnllkddlhpsfp
evsffhseenkapeseelemefedmenvpldrsshcqreeaggrdggsslgfkrsyeehi
pythmnggkkngaaataprsnpslessglevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6pxwA (A:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtncpatvingqfvercwth
shcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvetcpppy
yhfqdwrcvnfsfcqdlhhkcknsrchqyvihnnkcipecpsgytmnssnllctpclgpc
pkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlglieeisgyl
kirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnltitqgklff
hynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirtsfdkillr
wepywppdfrdllgfmlfykeapyqnvtefswtvvdidpplrsndpksqnhpgwlmrglk
pwtqyaifvktlvtfsderrtygaksdiiyvqtdqilkeleessfrktfedylhnvvfvp
r

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6pxwB (B:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtakgktncpatvingqfve
rcwthshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvet
cpppyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnll
ctpclgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgl
ieeisgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnlt
itqgklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirt
sfdkillrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrs
ndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpld
pisvsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsrtwsp
pfesedsqkhnqseyedsageccscpktdsqilkeleessfrktfedylhnvvfvprpsr
krrslgdvgnvtvavptvaafpntsstsvptspeehrpfekvvnkeslvisglrhftgyr
ielqacnqdtpeercsvaayvsartmpeakaddivgpvtheifennvvhlmwqepkepng
livlyevsyrrygdeelhlcvsrkhfalergcrlrglspgnysvriratslagngswtep
tyfyvtdyldvpsniakiiigplifvflfsvvigsiylflrkrqpdgplgplyassnpef
ltasdvfpcsvyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktv
nesaslrerieflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslr
peaennpgrppptlqemiqmaaeiadgmaylnakkfvhrnlaarncmvahdftvkigdfg
mtrdiyetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqg
lsneqvlkfvmdggyldqpdncpervtdlmrmcwqfnpkmrptfleivnllkddlhpsfp
evsffhseenkapeseelemefedmenvpldrsshcqreeaggrdggsslgfkrsyeehi
pythmnggkkngaaataprsnpslessglevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6pxwB (B:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtncpatvingqfvercwth
shcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvetcpppy
yhfqdwrcvnfsfcqdlhhkcknsrchqyvihnnkcipecpsgytmnssnllctpclgpc
pkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlglieeisgyl
kirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnltitqgklff
hynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirtsfdkillr
wepywppdfrdllgfmlfykeapyqnvtefswtvvdidpplrsndpksqnhpgwlmrglk
pwtqyaifvktlvtfsderrtygaksdiiyvqtdqilkeleessfrktfedylhnvvfvp
r

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.