PDB entry 6pxv

View 6pxv on RCSB PDB site
Description: cryo-em structure of full-length insulin receptor bound to 4 insulin. 3d refinement was focused on the extracellular region.
Deposited on 2019-07-27, released 2019-09-04
The last revision was dated 2019-09-04, with a file datestamp of 2019-08-30.
Experiment type: EM
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: INSR
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: INSR
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6pxvA (A:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtakgktncpatvingqfve
rcwthshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvet
cpppyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnll
ctpclgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgl
ieeisgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnlt
itqgklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirt
sfdkillrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrs
ndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpld
pisvsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsrtwsp
pfesedsqkhnqseyedsageccscpktdsqilkeleessfrktfedylhnvvfvprpsr
krrslgdvgnvtvavptvaafpntsstsvptspeehrpfekvvnkeslvisglrhftgyr
ielqacnqdtpeercsvaayvsartmpeakaddivgpvtheifennvvhlmwqepkepng
livlyevsyrrygdeelhlcvsrkhfalergcrlrglspgnysvriratslagngswtep
tyfyvtdyldvpsniakiiigplifvflfsvvigsiylflrkrqpdgplgplyassnpef
ltasdvfpcsvyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktv
nesaslrerieflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslr
peaennpgrppptlqemiqmaaeiadgmaylnakkfvhrnlaarncmvahdftvkigdfg
mtrdiyetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqg
lsneqvlkfvmdggyldqpdncpervtdlmrmcwqfnpkmrptfleivnllkddlhpsfp
evsffhseenkapeseelemefedmenvpldrsshcqreeaggrdggsslgfkrsyeehi
pythmnggkkngaaataprsnpslessglevlfq

    Sequence, based on observed residues (ATOM records):
    >6pxvA (A:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtncpatvingqfvercwth
shcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvetcpppy
yhfqdwrcvnfsfcqdlhhkcknsrchqyvihnnkcipecpsgytmnssnllctpclgpc
pkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlglieeisgyl
kirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnltitqgklff
hynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirtsfdkillr
wepywppdfrdllgfmlfykeapyqnvtefswtvvdidpplrsndpksqnhpgwlmrglk
pwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpldpisvsnsssqiilkwkp
psdpngnithylvfwerqaedselfeldyclkglklpsrqilkeleessfrktfedylhn
vvfvpreehrpfekvvnkeslvisglrhftgyrielqacnqdtpeercsvaayvsartmp
eakaddivgpvtheifennvvhlmwqepkepnglivlyevsyrrygdeelhlcvsrkhfa
lergcrlrglspgnysvriratslagngswteptyfyvtdyld

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6pxvC (C:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtakgktncpatvingqfve
rcwthshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvet
cpppyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnll
ctpclgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgl
ieeisgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnlt
itqgklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirt
sfdkillrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrs
ndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpld
pisvsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsrtwsp
pfesedsqkhnqseyedsageccscpktdsqilkeleessfrktfedylhnvvfvprpsr
krrslgdvgnvtvavptvaafpntsstsvptspeehrpfekvvnkeslvisglrhftgyr
ielqacnqdtpeercsvaayvsartmpeakaddivgpvtheifennvvhlmwqepkepng
livlyevsyrrygdeelhlcvsrkhfalergcrlrglspgnysvriratslagngswtep
tyfyvtdyldvpsniakiiigplifvflfsvvigsiylflrkrqpdgplgplyassnpef
ltasdvfpcsvyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktv
nesaslrerieflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslr
peaennpgrppptlqemiqmaaeiadgmaylnakkfvhrnlaarncmvahdftvkigdfg
mtrdiyetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqg
lsneqvlkfvmdggyldqpdncpervtdlmrmcwqfnpkmrptfleivnllkddlhpsfp
evsffhseenkapeseelemefedmenvpldrsshcqreeaggrdggsslgfkrsyeehi
pythmnggkkngaaataprsnpslessglevlfq

    Sequence, based on observed residues (ATOM records):
    >6pxvC (C:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednyivlnkddneecgdicpgtncpatvingqfvercwth
shcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvetcpppy
yhfqdwrcvnfsfcqdlhhkcknsrchqyvihnnkcipecpsgytmnssnllctpclgpc
pkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlglieeisgyl
kirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnltitqgklff
hynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirtsfdkillr
wepywppdfrdllgfmlfykeapyqnvtefswtvvdidpplrsndpksqnhpgwlmrglk
pwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpldpisvsnsssqiilkwkp
psdpngnithylvfwerqaedselfeldyclkglklpsrqilkeleessfrktfedylhn
vvfvpreehrpfekvvnkeslvisglrhftgyrielqacnqdtpeercsvaayvsartmp
eakaddivgpvtheifennvvhlmwqepkepnglivlyevsyrrygdeelhlcvsrkhfa
lergcrlrglspgnysvriratslagngswteptyfyvtdyld

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6pxvD (D:)
fvnqhlcgshlvealylvcgergffytpktrreaedlqgslqplalegslqkrgiveqcc
tsicslyqlenycn

    Sequence, based on observed residues (ATOM records):
    >6pxvD (D:)
vnqhlcgshlvealylvcgergffytpgiveqcctsicslyqlenycn

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6pxvE (E:)
fvnqhlcgshlvealylvcgergffytpktrreaedlqgslqplalegslqkrgiveqcc
tsicslyqlenycn

    Sequence, based on observed residues (ATOM records):
    >6pxvE (E:)
vnqhlcgshlvealylvcgergffytpgiveqcctsicslyqlenycn

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6pxvF (F:)
fvnqhlcgshlvealylvcgergffytpktrreaedlqgslqplalegslqkrgiveqcc
tsicslyqlenycn

    Sequence, based on observed residues (ATOM records):
    >6pxvF (F:)
qhlcgshlvealylvcgergffygiveqcctsicslyqlenycn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6pxvG (G:)
fvnqhlcgshlvealylvcgergffytpktrreaedlqgslqplalegslqkrgiveqcc
tsicslyqlenycn

    Sequence, based on observed residues (ATOM records):
    >6pxvG (G:)
qhlcgshlvealylvcgergffygiveqcctsicslyqlenycn