PDB entry 6pxr

View 6pxr on RCSB PDB site
Description: Anti-TAU BIIB092 FAB with TAU peptide
Class: immune system
Keywords: TAU, antibody, BIIB092, gosuranemab tau complex, IMMUNE SYSTEM
Deposited on 2019-07-26, released 2020-07-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-10, with a file datestamp of 2021-02-05.
Experiment type: XRAY
Resolution: 1.56 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: microtubule-associated protein tau
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPT, MAPTL, MTBT1, TAU
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: gosuranemab Fab, heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6PXR
    Domains in SCOPe 2.08: d6pxrh_
  • Chain 'L':
    Compound: gosuranemab Fab, light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6PXR (0-101)
    • Uniprot A2NHM3 (102-End)
    Domains in SCOPe 2.08: d6pxrl1, d6pxrl2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6pxrH (H:)
evhlvesggalvkpggslklscaasgfsfskygmswvrqtpdkrlewvatisssgsrtyy
pdsvkgqftisrdnakntlylqmsslksedtamyycsiswdgamdywgqgtsvtvssakt
tppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlyt
lsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcgckpc

    Sequence, based on observed residues (ATOM records): (download) 
    >6pxrH (H:)
vhlvesggalvkpggslklscaasgfsfskygmswvrqtpdkrlewvatisssgsrtyyp
dsvkgqftisrdnakntlylqmsslksedtamyycsiswdgamdywgqgtsvtvssaktt
ppsvyplapgssmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssvt
vpsstwpsetvtcnvahpasstkvdkkivprd

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6pxrL (L:)
dvlmtqtplslpvslgdqasisckssqsivhsngntylewylqkpgqspkllvykvsnrf
sgvpdrfsgsgsgtdftlkisrveaedlgtyycfqgslvpwafgggtkleikradaaptv
sifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysm
sstltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6pxrL (L:)
dvlmtqtplslpvslgdqasisckssqsivhsngntylewylqkpgqspkllvykvsnrf
sgvpdrfsgsgsgtdftlkisrveaedlgtyycfqgslvpwafgggtkleikradaaptv
sifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysm
sstltltkdeyerhnsytceathktstspivksfnrne