PDB entry 6pww

View 6pww on RCSB PDB site
Description: cryo-em structure of mll1 in complex with rbbp5 and wdr5 bound to the nucleosome
Deposited on 2019-07-23, released 2019-12-18
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: EM
Resolution: 4.4 Å
R-factor: N/A
AEROSPACI score: 0.02 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoblastoma-binding protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: RBBP5, RBQ3
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Histone-lysine N-methyltransferase 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03164 (Start-208)
      • conflict (100)
      • conflict (106)
  • Chain 'G':
    Compound: Histone H3.2
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P84233
      • engineered mutation (102)
  • Chain 'H':
    Compound: histone h4
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Histone H2A type 1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06897
      • conflict (98)
  • Chain 'J':
    Compound: Histone H2B 1.1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02281
      • engineered mutation (29)
  • Chain 'K':
    Compound: Histone H3.2
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P84233
      • engineered mutation (102)
  • Chain 'L':
    Compound: histone h4
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: Histone H2A type 1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06897
      • conflict (98)
  • Chain 'N':
    Compound: Histone H2B 1.1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02281
      • engineered mutation (29)
  • Chain 'O':
    Compound: DNA (146-mer)
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'P':
    Compound: DNA (146-mer)
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: SAH, ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6pwwA (A:)
snlellesfgqnypeeadgtldcismaltctfnrwgtllavgcndgriviwdfltrgiak
iisahihpvcslcwsrdghklvsastdnivsqwdvlsgdcdqrfrfpspilkvqyhprdq
nkvlvcpmksapvmltlsdskhvvlpvdddsdlnvvasfdrrgeyiytgnakgkilvlkt
dsqdlvasfrvttgtsnttaiksiefarkgscflintadriirvydgreiltcgrdgepe
pmqklqdlvnrtpwkkccfsgdgeyivagsarqhalyiweksignlvkilhgtrgellld
vawhpvrpiiasissgvvsiwaqnqvenwsafapdfkeldenveyeeresefdiededks
epeqtgadaaedeevdvtsvdpiaafcssdeeledskallylpiapevedpeenpygppp
davqtslmdegassekkrqssadgsqppkkkpkttnielqgvpndevhpllgvkgdgksk
kkqagrpkgskgkekdspfkpklykgdrglplegsakgkvqaelsqpltaggaisell

    Sequence, based on observed residues (ATOM records):
    >6pwwA (A:)
dgtldcismaltctfnrwgtllavgcndgriviwdfltrgiakiisahihpvcslcwsrd
ghklvsastdnivsqwdvlsgdcdqrfrfpspilkvqyhprdqnkvlvcpmksapvmltl
sdskhvvlpvdddsdlnvvasfdrrgeyiytgnakgkilvlktdsqdlvasfrvttgtsn
ttaiksiefarkgscflintadriirvydgreiltcgrdgepepmqklqdlvnrtpwkkc
cfsgdgeyivagsarqhalyiweksignlvkilhgtrgellldvawhpvrpiiasissgv
vsiwaqnqvenwsafkeldenveyeeresefdi

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6pwwB (B:)
satqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfek
tisghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqs
nlivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdta
sgqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyc
ifanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaal
endktiklwksdc

    Sequence, based on observed residues (ATOM records):
    >6pwwB (B:)
kpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgis
dvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfde
svriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktlid
ddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtgg
kwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwk
sdc

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6pwwC (C:)
sgsaraevhlrksafdmfnflaskhrqppeynpndeeeeevqlksarratsmdlpmpmrf
rhlkktskeavgvyrspihgrglfckrnidagemvieyagivirsiltdkrekyydskgi
gcymfriddsevvdatmhgnaarfinhscepncysrvinidgqkhivifamrkiyrgeel
tydykfpiedasnklpcncgakkcrkfln

    Sequence, based on observed residues (ATOM records):
    >6pwwC (C:)
lpmpmrfrhlkktskeavgvyrspihgrglfckrnidagemvieyagivirsiltdkrek
yydskgigcymfriddsevvdatmhgnaarfinhscepncysrvinidgqkhivifamrk
iyrgeeltydykfpiedklpcncgakkcrkfln

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6pwwG (G:)
martkqtarkstggkaprkqlatkaarksapatggvkkphryrpgtvalreirryqkste
llirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvalfedtnlcaihakrvti
mpkdiqlarrirgera

    Sequence, based on observed residues (ATOM records):
    >6pwwG (G:)
kphryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqeas
eaylvalfedtnlcaihakrvtimpkdiqlarrirger

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6pwwH (H:)
msgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlk
vflenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records):
    >6pwwH (H:)
kvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrk
tvtamdvvyalkrqgrtlygfg

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6pwwI (I:)
sgrgkqggktrakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleylta
eilelagnaardnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpkkt
essksaksk

    Sequence, based on observed residues (ATOM records):
    >6pwwI (I:)
akaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagnaar
dnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpk

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6pwwJ (J:)
maksapapkkgskkavtktqkkdgkkrrktrkesyaiyvykvlkqvhpdtgisskamsim
nsfvndvferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtkyt
sak

    Sequence, based on observed residues (ATOM records):
    >6pwwJ (J:)
trkesyaiyvykvlkqvhpdtgisskamsimnsfvndvferiageasrlahynkrstits
reiqtavrlllpgelakhavsegtkavtkytsa

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6pwwK (K:)
martkqtarkstggkaprkqlatkaarksapatggvkkphryrpgtvalreirryqkste
llirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvalfedtnlcaihakrvti
mpkdiqlarrirgera

    Sequence, based on observed residues (ATOM records):
    >6pwwK (K:)
kphryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqeas
eaylvalfedtnlcaihakrvtimpkdiqlarrirger

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6pwwL (L:)
msgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlk
vflenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records):
    >6pwwL (L:)
kvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrk
tvtamdvvyalkrqgrtlygfg

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6pwwM (M:)
sgrgkqggktrakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleylta
eilelagnaardnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpkkt
essksaksk

    Sequence, based on observed residues (ATOM records):
    >6pwwM (M:)
akaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagnaar
dnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpk

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6pwwN (N:)
maksapapkkgskkavtktqkkdgkkrrktrkesyaiyvykvlkqvhpdtgisskamsim
nsfvndvferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtkyt
sak

    Sequence, based on observed residues (ATOM records):
    >6pwwN (N:)
trkesyaiyvykvlkqvhpdtgisskamsimnsfvndvferiageasrlahynkrstits
reiqtavrlllpgelakhavsegtkavtkytsa

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.