PDB entry 6pwc

View 6pwc on RCSB PDB site
Description: a complex structure of arrestin-2 bound to neurotensin receptor 1
Deposited on 2019-07-22, released 2019-12-04
The last revision was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: EM
Resolution: 4.9 Å
R-factor: N/A
AEROSPACI score: -0 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-arrestin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARRB1, ARR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49407
      • conflict (80)
      • conflict (278)
  • Chain 'B':
    Compound: Neurotensin peptide
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6PWC (Start-5)
  • Chain 'H':
    Compound: Fab30 heavy chain
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6PWC
  • Chain 'L':
    Compound: Fab30 light chain
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6PWC (0-End)
  • Chain 'R':
    Compound: Neurotensin receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NTSR1, NTRR
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6pwcA (A:)
mgdkgtrvfkkaspngkltvylgkrdfvdhidlvdpvdgvvlvdpeylkerrvyvtltca
frygredldvlgltfrkdlfcanvqsfppapedkkpltrlqerlikklgehaypftfeip
pnlpcsvtlqpgpedtgkacgvdyevkafcaenleekihkrnsvrlvirkvqyaperpgp
qptaettrqflmsdkplhleasldkeiyyhgepisvnvhvtnntnktvkkikisvrqyad
iclfntaqykcpvameeaddtvapsstfckvytltpflcnnrekrglaldgklkhedtnl
asstllreganreilgiivsykvkvklvvsrggllgdlassdvavelpftlmhpkpkeep
phrevpenetpvdtnlieldtndddaaaedfar

    Sequence, based on observed residues (ATOM records):
    >6pwcA (A:)
rvfkkaspngkltvylgkrdfvdhidlvdpvdgvvlvdpeylkerrvyvtltcafrygre
dldvlgltfrkdlfcanvqsfppapedkkpltrlqerlikklgehaypftfeippnlpcs
vtlqpgpedtgkacgvdyevkafcaenleekihkrnsvrlvirkvqyaperpgpqptaet
trqflmsdkplhleasldkeiyyhgepisvnvhvtnntnktvkkikisvrqyadiclfnt
aqykcpvameeaddtvapsstfckvytltpflcnnrekrglaldgklkhedtnlasstll
reganreilgiivsykvkvklvvsrggllgdlassdvavelpftlmhpkp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6pwcB (B:)
rrpyil

    Sequence, based on observed residues (ATOM records):
    >6pwcB (B:)
rpyil

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6pwcH (H:)
meisevqlvesggglvqpggslrlscaasgfnvysssihwvrqapgkglewvasissyyc
ytyyadsvkgrftisadtskntaylqmnslraedtavyycarsrqfwysgldywgqgtlv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6pwcH (H:)
vqlvesggglvqpggslrlscaasgfnvysssihwvrqapgkglewvasissyycytyya
dsvkgrftisadtskntaylqmnslraedtavyycarsrqfwysgldywgqgtlvtvssa
stkgpsvfpllgclvkdyfpepvtvswnsgalgvhtfpavlqssglyslssvvtvpyicn
vnhkpsntkvdkkv

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6pwcL (L:)
sdiqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvp
srfsgsrsgtdftltisslqpedfatyycqqykyvpvtfgqgtkveikrtvaapsvfifp
psdsqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6pwcL (L:)
sdiqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvp
srfsgsrsgtdftltisslqpedfatyycqqykyvpvtfgqgtkveikrtvaapsvfifp
psdsqlkasvvcllnnfypreakvqwkvqsgnsqesvteqdskdstyslsstltlskady
ekh

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6pwcR (R:)
apsseldvntdiyskvlvtavylalfvvgtvgntvtaftlarkkslqslqstvhyhlgsl
alsdlltlllampvelynfiwvhhpwafgdagcrgyyflrdactyatalnvaslsveryl
aichpfkaktlmsrsrtkkfisaiwlasallavpmlftmgeqnrsadgqhagglvctpti
htatvkvviqvntfmsfifpmvvisvlntiiankltvmvrqaaeqgqvctvggehstfsm
aiepgrvqalrhgvrvlravviafvvcwlpyhvrrlmfcyisdeqwtpflydfyhyfymv
tnalfyvsstinpilynlvsanfrhiflatlaclcpvwrrrrkrpafsrkadsvssnhtl
ssnatretly

    Sequence, based on observed residues (ATOM records):
    >6pwcR (R:)
apsseldvntdiyskvlvtavylalfvvgtvgntvtaftlarkkslqslqstvhyhlgsl
alsdlltlllampvelynfiwvhhpwafgdagcrgyyflrdactyatalnvaslsveryl
aichpfkaktlmsrsrtkkfisaiwlasallavpmlftmgeqnrsadgqhagglvctpti
htatvkvviqvntfmsfifpmvvisvlntiiankltvmvrqgrvqalrhgvrvlravvia
fvvcwlpyhvrrlmfcyisdeqwtpflydfyhyfymvtnalfyvsstinpilynlvsanf
rhiflatlaclchtlssnatret