PDB entry 6ptp

View 6ptp on RCSB PDB site
Description: Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with tetrahedral intermediate mimic KVS-1
Class: hydrolase
Keywords: HIV-1 protease, aspartic protease, homodimer, HYDROLASE
Deposited on 2019-07-16, released 2020-06-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-17, with a file datestamp of 2020-06-12.
Experiment type: XRAYNEUT
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: hiv-1 protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7SSI0
    • engineered mutation (6)
    • engineered mutation (31-32)
    • engineered mutation (46)
    • engineered mutation (62)
    • engineered mutation (66)
    • engineered mutation (81)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d6ptpa_
• Chain 'B':
  Compound: hiv-1 protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7SSI0 (0-98)
    • engineered mutation (6)
    • engineered mutation (31-32)
    • engineered mutation (46)
    • engineered mutation (62)
    • engineered mutation (66)
    • engineered mutation (81)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d6ptpb_
• Heterogens: KVS, DOD

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6ptpA (A:)
  pqitlwkrplvtikiggqlkealldtgaddtiieemslpgrwkpkmvggiggfikvrqyd
  qiiieiaghkaigtvlvgptpiniigrnlltqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6ptpB (B:)
  pqitlwkrplvtikiggqlkealldtgaddtiieemslpgrwkpkmvggiggfikvrqyd
  qiiieiaghkaigtvlvgptpiniigrnlltqigatlnf