PDB entry 6pt1

View 6pt1 on RCSB PDB site
Description: Crystal Structure of Class D Beta-lactamase OXA-48 with Meropenem
Class: hydrolase
Keywords: Carbapenemase, Carbapenem, substrate, Hydrolyzed product, HYDROLASE
Deposited on 2019-07-14, released 2020-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Class D Carbapenemase OXA-48
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (16-21)
    Domains in SCOPe 2.08: d6pt1a1, d6pt1a2
  • Chain 'B':
    Compound: Class D Carbapenemase OXA-48
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (19-21)
    Domains in SCOPe 2.08: d6pt1b1, d6pt1b2
  • Chain 'C':
    Compound: Class D Carbapenemase OXA-48
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (16-21)
    Domains in SCOPe 2.08: d6pt1c1, d6pt1c2
  • Chain 'D':
    Compound: Class D Carbapenemase OXA-48
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (19-21)
    Domains in SCOPe 2.08: d6pt1d1, d6pt1d2
  • Heterogens: MER, CL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pt1A (A:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6pt1A (A:)
nlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnsl
ialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskm
lhafdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlte
angdyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevl
kqekiip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6pt1B (B:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6pt1B (B:)
fqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6pt1C (C:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6pt1C (C:)
nlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnsl
ialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskm
lhafdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlte
angdyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevl
kqekiip

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6pt1D (D:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6pt1D (D:)
fqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip