PDB entry 6prw

View 6prw on RCSB PDB site
Description: crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
Deposited on 2019-07-11, released 2020-07-22
The last revision was dated 2020-07-22, with a file datestamp of 2020-07-17.
Experiment type: XRAY
Resolution: 2.61 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Propionyl-CoA carboxylase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: accD6, DSI35_30190, ERS023446_01401, ERS024213_00063, ERS027644_00734, ERS027646_00895, ERS027651_00104, ERS027653_02606, ERS027656_00219, ERS027666_02199, ERS031537_00601, ERS124361_03148, SAMEA2682864_00423, SAMEA2683035_01247
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Propionyl-CoA carboxylase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: accD6, DSI35_30190, ERS023446_01401, ERS024213_00063, ERS027644_00734, ERS027646_00895, ERS027651_00104, ERS027653_02606, ERS027656_00219, ERS027666_02199, ERS031537_00601, ERS124361_03148, SAMEA2682864_00423, SAMEA2683035_01247
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Propionyl-CoA carboxylase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: accD6, DSI35_30190, ERS023446_01401, ERS024213_00063, ERS027644_00734, ERS027646_00895, ERS027651_00104, ERS027653_02606, ERS027656_00219, ERS027666_02199, ERS031537_00601, ERS124361_03148, SAMEA2682864_00423, SAMEA2683035_01247
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Propionyl-CoA carboxylase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: accD6, DSI35_30190, ERS023446_01401, ERS024213_00063, ERS027644_00734, ERS027646_00895, ERS027651_00104, ERS027653_02606, ERS027656_00219, ERS027666_02199, ERS031537_00601, ERS124361_03148, SAMEA2682864_00423, SAMEA2683035_01247
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Propionyl-CoA carboxylase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: accD6, DSI35_30190, ERS023446_01401, ERS024213_00063, ERS027644_00734, ERS027646_00895, ERS027651_00104, ERS027653_02606, ERS027656_00219, ERS027666_02199, ERS031537_00601, ERS124361_03148, SAMEA2682864_00423, SAMEA2683035_01247
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Propionyl-CoA carboxylase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: accD6, DSI35_30190, ERS023446_01401, ERS024213_00063, ERS027644_00734, ERS027646_00895, ERS027651_00104, ERS027653_02606, ERS027656_00219, ERS027666_02199, ERS031537_00601, ERS124361_03148, SAMEA2682864_00423, SAMEA2683035_01247
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Propionyl-CoA carboxylase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: accD6, DSI35_30190, ERS023446_01401, ERS024213_00063, ERS027644_00734, ERS027646_00895, ERS027651_00104, ERS027653_02606, ERS027656_00219, ERS027666_02199, ERS031537_00601, ERS124361_03148, SAMEA2682864_00423, SAMEA2683035_01247
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Propionyl-CoA carboxylase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: accD6, DSI35_30190, ERS023446_01401, ERS024213_00063, ERS027644_00734, ERS027646_00895, ERS027651_00104, ERS027653_02606, ERS027656_00219, ERS027666_02199, ERS031537_00601, ERS124361_03148, SAMEA2682864_00423, SAMEA2683035_01247
    Database cross-references and differences (RAF-indexed):
  • Heterogens: OWD, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6prwA (A:)
mtimapeavgesldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctd
gtvmggamgvegcthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamir
asgyipqisvvvgfaaggaaygpaltdvvvmapesrvfvtgpdvvrsvtgedvdmaslgg
pethhkksgvchivaddeldaydrgrrlvglfcqqghfdrskaeagdtdihallpessrr
aydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvlannplrlggclnsesa
ekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakllhafgectvprvtlvt
rktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkkklaaapeherealhdq
laaeheriaggvdsaldigvvdekidpahtrskltealaqaparrgrhknipl

    Sequence, based on observed residues (ATOM records):
    >6prwA (A:)
ldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctdgtvmggamgveg
cthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamirasgyipqisvvv
gfaaggaaygpaltdvvvmapesrvfvsgvchivaddeldaydrgrrlvglfcqqghfdr
skaeagdtdihallpessrraydvrpivtaildadtpfdefqanwapsmvvglgrlsgrt
vgvlannplrlggclnsesaekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrr
gakllhafgectvprvtlvtrktyggayiamnsrslnatkvfawpdaevavmgakaavgi
lhkkklaaapeherealhdqlaaeheriaggvdsaldigvvdekidpahtrskltealaq
aparrg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6prwB (B:)
mtimapeavgesldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctd
gtvmggamgvegcthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamir
asgyipqisvvvgfaaggaaygpaltdvvvmapesrvfvtgpdvvrsvtgedvdmaslgg
pethhkksgvchivaddeldaydrgrrlvglfcqqghfdrskaeagdtdihallpessrr
aydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvlannplrlggclnsesa
ekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakllhafgectvprvtlvt
rktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkkklaaapeherealhdq
laaeheriaggvdsaldigvvdekidpahtrskltealaqaparrgrhknipl

    Sequence, based on observed residues (ATOM records):
    >6prwB (B:)
ldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctdgtvmggamgveg
cthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamirasgyipqisvvv
gfaaggaaygpaltdvvvmapeskksgvchivaddeldaydrgrrlvglfcqqghfdrsk
aeagdtdihallpessrraydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvg
vlannplrlggclnsesaekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrga
kllhafgectvprvtlvtrktyggayiamnsrslnatkvfawpdaevavmgakaavgilh
kkklaaapeherealhdqlaaeheriaggvdsaldigvvdekidpahtrskltealaqap
arrg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6prwC (C:)
mtimapeavgesldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctd
gtvmggamgvegcthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamir
asgyipqisvvvgfaaggaaygpaltdvvvmapesrvfvtgpdvvrsvtgedvdmaslgg
pethhkksgvchivaddeldaydrgrrlvglfcqqghfdrskaeagdtdihallpessrr
aydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvlannplrlggclnsesa
ekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakllhafgectvprvtlvt
rktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkkklaaapeherealhdq
laaeheriaggvdsaldigvvdekidpahtrskltealaqaparrgrhknipl

    Sequence, based on observed residues (ATOM records):
    >6prwC (C:)
ldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctdgtvmggamgveg
cthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamirasgyipqisvvv
gfaaggaaygpaltdvvvmapessgvchivaddeldaydrgrrlvglfcqqghfdrskae
agdtdihallpessrraydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvl
annplrlggclnsesaekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakl
lhafgectvprvtlvtrktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkk
klaqlaaeheriaggvdsaldigvvdekidpahtrskltealaqaparrg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6prwD (D:)
mtimapeavgesldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctd
gtvmggamgvegcthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamir
asgyipqisvvvgfaaggaaygpaltdvvvmapesrvfvtgpdvvrsvtgedvdmaslgg
pethhkksgvchivaddeldaydrgrrlvglfcqqghfdrskaeagdtdihallpessrr
aydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvlannplrlggclnsesa
ekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakllhafgectvprvtlvt
rktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkkklaaapeherealhdq
laaeheriaggvdsaldigvvdekidpahtrskltealaqaparrgrhknipl

    Sequence, based on observed residues (ATOM records):
    >6prwD (D:)
ldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctdgtvmggamgveg
cthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamirasgyipqisvvv
gfaaggaaygpaltdvvvmapesrvfvtgsgvchivaddeldaydrgrrlvglfcqqghf
drskaeagdtdihallpessrraydvrpivtaildadtpfdefqanwapsmvvglgrlsg
rtvgvlannplrlggclnsesaekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvv
rrgakllhafgectvprvtlvtrktyggayiamnsrslnatkvfawpdaevavmgakaav
gilhkkklaaapeherealhdqlaaeheriaggvdsaldigvvdekidpahtrsklteal
aqaparrg

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6prwE (E:)
mtimapeavgesldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctd
gtvmggamgvegcthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamir
asgyipqisvvvgfaaggaaygpaltdvvvmapesrvfvtgpdvvrsvtgedvdmaslgg
pethhkksgvchivaddeldaydrgrrlvglfcqqghfdrskaeagdtdihallpessrr
aydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvlannplrlggclnsesa
ekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakllhafgectvprvtlvt
rktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkkklaaapeherealhdq
laaeheriaggvdsaldigvvdekidpahtrskltealaqaparrgrhknipl

    Sequence, based on observed residues (ATOM records):
    >6prwE (E:)
ldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctdgtvmggamgveg
cthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamirasgyipqisvvv
gfaaggaaygpaltdvvvmapesrvfvsgvchivaddeldaydrgrrlvglfcqqghfdr
skaeagdtdihallpessrraydvrpivtaildadtpfdefqanwapsmvvglgrlsgrt
vgvlannplrlggclnsesaekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrr
gakllhafgectvprvtlvtrktyggayiamnsrslnatkvfawpdaevavmgakaavgi
lhkkklaaapeherealhdqlaaeheriaggvdsaldigvvdekidpahtrskltealaq
aparrg

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6prwF (F:)
mtimapeavgesldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctd
gtvmggamgvegcthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamir
asgyipqisvvvgfaaggaaygpaltdvvvmapesrvfvtgpdvvrsvtgedvdmaslgg
pethhkksgvchivaddeldaydrgrrlvglfcqqghfdrskaeagdtdihallpessrr
aydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvlannplrlggclnsesa
ekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakllhafgectvprvtlvt
rktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkkklaaapeherealhdq
laaeheriaggvdsaldigvvdekidpahtrskltealaqaparrgrhknipl

    Sequence, based on observed residues (ATOM records):
    >6prwF (F:)
ldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctdgtvmggamgveg
cthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamirasgyipqisvvv
gfaaggaaygpaltdvvvmapeskksgvchivaddeldaydrgrrlvglfcqqghfdrsk
aeagdtdihallpessrraydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvg
vlannplrlggclnsesaekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrga
kllhafgectvprvtlvtrktyggayiamnsrslnatkvfawpdaevavmgakaavgilh
kkklaaapeherealhdqlaaeheriaggvdsaldigvvdekidpahtrskltealaqap
arrg

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6prwG (G:)
mtimapeavgesldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctd
gtvmggamgvegcthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamir
asgyipqisvvvgfaaggaaygpaltdvvvmapesrvfvtgpdvvrsvtgedvdmaslgg
pethhkksgvchivaddeldaydrgrrlvglfcqqghfdrskaeagdtdihallpessrr
aydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvlannplrlggclnsesa
ekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakllhafgectvprvtlvt
rktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkkklaaapeherealhdq
laaeheriaggvdsaldigvvdekidpahtrskltealaqaparrgrhknipl

    Sequence, based on observed residues (ATOM records):
    >6prwG (G:)
ldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctdgtvmggamgveg
cthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamirasgyipqisvvv
gfaaggaaygpaltdvvvmapessgvchivaddeldaydrgrrlvglfcqqghfdrskae
agdtdihallpessrraydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvl
annplrlggclnsesaekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakl
lhafgectvprvtlvtrktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkk
klaqlaaeheriaggvdsaldigvvdekidpahtrskltealaqaparrg

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6prwH (H:)
mtimapeavgesldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctd
gtvmggamgvegcthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamir
asgyipqisvvvgfaaggaaygpaltdvvvmapesrvfvtgpdvvrsvtgedvdmaslgg
pethhkksgvchivaddeldaydrgrrlvglfcqqghfdrskaeagdtdihallpessrr
aydvrpivtaildadtpfdefqanwapsmvvglgrlsgrtvgvlannplrlggclnsesa
ekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvvrrgakllhafgectvprvtlvt
rktyggayiamnsrslnatkvfawpdaevavmgakaavgilhkkklaaapeherealhdq
laaeheriaggvdsaldigvvdekidpahtrskltealaqaparrgrhknipl

    Sequence, based on observed residues (ATOM records):
    >6prwH (H:)
ldprdpllrlsnffddgsvellherdrsgvlaaagtvngvrtiafctdgtvmggamgveg
cthivnaydtaiedqspivgiwhsggarlaegvralhavgqvfeamirasgyipqisvvv
gfaaggaaygpaltdvvvmapesrvfvtgsgvchivaddeldaydrgrrlvglfcqqghf
drskaeagdtdihallpessrraydvrpivtaildadtpfdefqanwapsmvvglgrlsg
rtvgvlannplrlggclnsesaekaarfvrlcdafgiplvvvvdvpgylpgvdqewggvv
rrgakllhafgectvprvtlvtrktyggayiamnsrslnatkvfawpdaevavmgakaav
gilhkkklaaapeherealhdqlaaeheriaggvdsaldigvvdekidpahtrsklteal
aqaparrg