PDB entry 6pqi

View 6pqi on RCSB PDB site
Description: Crystal Structure of Class D Beta-lactamase OXA-48 with Cefotaxime
Class: hydrolase
Keywords: Carbapenemase, Carbapenem, substrate, Hydrolyzed product, HYDROLASE
Deposited on 2019-07-09, released 2020-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Class D Carbapenemase OXA-48
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (16-21)
    Domains in SCOPe 2.08: d6pqia1, d6pqia2
  • Chain 'B':
    Compound: Class D Carbapenemase OXA-48
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (18-21)
    Domains in SCOPe 2.08: d6pqib1, d6pqib2
  • Chain 'C':
    Compound: Class D Carbapenemase OXA-48
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (15-21)
    Domains in SCOPe 2.08: d6pqic1, d6pqic2
  • Chain 'D':
    Compound: Class D Carbapenemase OXA-48
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaOXA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A482LRD5 (22-262)
      • expression tag (19-21)
    Domains in SCOPe 2.08: d6pqid1, d6pqid2
  • Heterogens: CEF, CL, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pqiA (A:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6pqiA (A:)
nlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnsl
ialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskm
lhafdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlte
angdyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevl
kqekiip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6pqiB (B:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6pqiB (B:)
yfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslia
ldlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlh
afdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamltean
gdyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkq
ekiip

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6pqiC (C:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6pqiC (C:)
enlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipns
lialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmsk
mlhafdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlt
eangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkev
lkqekiip

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6pqiD (D:)
mkhhhhhhmhhhhhhenlyfqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkra
nqaflpastfkipnslialdlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpv
yqefarqigearmskmlhafdygnedisgnvdsfwldggirisateqisflrklyhnklh
vsersqrivkqamlteangdyiiraktgystriepkigwwvgwvelddnvwffamnmdmp
tsdglglrqaitkevlkqekiip

    Sequence, based on observed residues (ATOM records): (download) 
    >6pqiD (D:)
fqgwqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslial
dlgvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlha
fdygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteang
dyiiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqe
kiip