PDB entry 6pnx

View 6pnx on RCSB PDB site
Description: Crystal Structure of an Asymmetric Dimer of FGF Receptor 3 Kinases Trapped in A-loop Tyrosine Transphosphorylation Reaction
Class: transferase
Keywords: Tyrosine kinase, Transphosphorylation, Asymmetric dimer, TRANSFERASE
Deposited on 2019-07-03, released 2020-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 3
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR3, JTK4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22607
      • engineered mutation (46)
      • engineered mutation (233)
    Domains in SCOPe 2.08: d6pnxa_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 3
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR3, JTK4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22607
      • engineered mutation (46)
      • engineered mutation (233)
    Domains in SCOPe 2.08: d6pnxb_
  • Heterogens: ACP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pnxA (A:)
mgsshhhhhhsqdptlanvselelpadpkwelsrarltlgkplgegafgqvvmaeaigid
kdraakpvtvavkmlkddatdkdlsdlvsememmkmigkhkniinllgactqggplyvlv
eyaakgnlreflrarrppgldysfdtskppeeqltfkdlvscayqvargmeylasqkcih
rdlaarnvlvtednvmkiadfglardvhnldyykkttngrlpvkwmapealfdevythqs
dvwsfgvllweiftlggspypgipveelfkllkeghrmdkpancthdlymimrecwhaap
sqrptfkqlvedldrvltvtstde

    Sequence, based on observed residues (ATOM records): (download) 
    >6pnxA (A:)
elelpadpkwelsrarltlgkplgegafgqvvmaeaigidkdraakpvtvavkmlkddat
dkdlsdlvsememmkmigkhkniinllgactqggplyvlveyaakgnlreflrarrpppe
eqltfkdlvscayqvargmeylasqkcihrdlaarnvlvtednvmkiadfglardvhnld
yykkttngrlpvkwmapealfdevythqsdvwsfgvllweiftlggspypgipveelfkl
lkeghrmdkpancthdlymimrecwhaapsqrptfkqlvedldrvltvtst

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6pnxB (B:)
mgsshhhhhhsqdptlanvselelpadpkwelsrarltlgkplgegafgqvvmaeaigid
kdraakpvtvavkmlkddatdkdlsdlvsememmkmigkhkniinllgactqggplyvlv
eyaakgnlreflrarrppgldysfdtskppeeqltfkdlvscayqvargmeylasqkcih
rdlaarnvlvtednvmkiadfglardvhnldyykkttngrlpvkwmapealfdevythqs
dvwsfgvllweiftlggspypgipveelfkllkeghrmdkpancthdlymimrecwhaap
sqrptfkqlvedldrvltvtstde

    Sequence, based on observed residues (ATOM records): (download) 
    >6pnxB (B:)
selelpadpkwelsrarltlgkplgegafgqvvmaeaigidkdraakpvtvavkmlkdda
tdkdlsdlvsememmkmigkhkniinllgactqggplyvlveyaakgnlreflrarrppg
ldpeeqltfkdlvscayqvargmeylasqkcihrdlaarnvlvtednvmkiadfglardv
hnldyykkttngrlpvkwmapealfdevythqsdvwsfgvllweiftlggspypgipvee
lfkllkeghrmdkpancthdlymimrecwhaapsqrptfkqlvedldrvltvts