PDB entry 6pkc

View 6pkc on RCSB PDB site
Description: Inhibition of Human Menin by VTP-50469
Class: transcription
Keywords: Human Menin, Transcription, Inhibitor Complex, VTP-50469
Deposited on 2019-06-29, released 2019-12-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Menin,Menin
    Species: Homo sapiens [TaxId:9606]
    Gene: MEN1, SCG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00255 (2-457)
      • engineered mutation (5)
    • Uniprot O00255 (458-489)
    Domains in SCOPe 2.08: d6pkca1
  • Chain 'B':
    Compound: Menin,Menin
    Species: Homo sapiens [TaxId:9606]
    Gene: MEN1, SCG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00255 (2-457)
      • engineered mutation (5)
    • Uniprot O00255 (458-End)
    Domains in SCOPe 2.08: d6pkcb1
  • Heterogens: OP4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pkcA (A:)
gsglktaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvp
eltfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvk
kvsdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalse
dhawvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafm
vcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpl
tlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredee
iykeffevandvipnllkeaaslleageerpgeqsqgtqsqgsalqdpecfahllrfydg
ickweegsptpvlhvgwatflvqslgrfegqvrqkvritfqsekmkgmkellvatkinss
aiklqltaqs

    Sequence, based on observed residues (ATOM records): (download) 
    >6pkcA (A:)
glktaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrspapdppgg
ltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkvsdviwnslsrsyf
kdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedhawvvfgpngeqta
evtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmvcainpsidlhtdsl
ellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpltlyhkgiasaktyyr
dehiypymylagyhcrnrnvrealqawadtatviqdynycredeeiykeffevandvipn
llkeaaslleagegsalqdpecfahllrfydgickweegsptpvlhvgwatflvqslgrf
egqvrqkvritfqsekmkgmkellvatkinssaiklqltaqs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6pkcB (B:)
gsglktaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvp
eltfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvk
kvsdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalse
dhawvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafm
vcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpl
tlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredee
iykeffevandvipnllkeaaslleageerpgeqsqgtqsqgsalqdpecfahllrfydg
ickweegsptpvlhvgwatflvqslgrfegqvrqkvritfqsekmkgmkellvatkinss
aiklqltaqs

    Sequence, based on observed residues (ATOM records): (download) 
    >6pkcB (B:)
glktaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrspapdppgg
ltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkvsdviwnslsrsyf
kdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedhawvvfgpngeqta
evtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmvcainpsidlhtdsl
ellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpltlyhkgiasaktyyr
dehiypymylagyhcrnrnvrealqawadtatviqdynycredeeiykeffevandvipn
llkeaaslleagegsalqdpecfahllrfydgickweegsptpvlhvgwatflvqslgrf
egqvrqkvritfqsekmkgmkellvatkinssaiklqltaq