PDB entry 6pay

View 6pay on RCSB PDB site
Description: Structure of HsICDH1:Mg(II):ICT:NADPH(50%) complex reveals structural basis for observation of half-sites reactivity
Class: oxidoreductase
Keywords: substrate complex, half-sites reactivity, ICDH mechanism, OXIDOREDUCTASE
Deposited on 2019-06-12, released 2019-09-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6paya_
  • Chain 'B':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6payb_
  • Chain 'C':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6payc_
  • Chain 'D':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6payd_
  • Heterogens: ICT, MG, NDP, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6payA (A:)
mskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkda
aeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprl
vsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvam
gmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfe
aqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdg
ktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanale
evsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >6payA (A:)
kisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaea
ikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsg
wvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmy
nqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqk
iwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktv
eaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevs
ietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6payB (B:)
mskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkda
aeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprl
vsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvam
gmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfe
aqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdg
ktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanale
evsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >6payB (B:)
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6payC (C:)
mskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkda
aeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprl
vsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvam
gmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfe
aqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdg
ktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanale
evsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >6payC (C:)
isggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaeai
kkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsgw
vkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmyn
qdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqki
wyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktve
aeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsi
etieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6payD (D:)
mskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkda
aeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprl
vsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvam
gmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfe
aqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdg
ktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanale
evsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >6payD (D:)
isggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaeai
kkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsgw
vkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmyn
qdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqki
wyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktve
aeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsi
etieagfmtkdlaacikglpnrsdylntfefmdklgenlkiklaqa