PDB entry 6p95

View 6p95 on RCSB PDB site
Description: structure of lassa virus glycoprotein in complex with fab 25.6a
Deposited on 2019-06-09, released 2019-09-11
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-09.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pre-glycoprotein polyprotein GP complex
    Species: Lassa virus [TaxId:11622]
    Gene: GPC, GP-C
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08669
      • engineered mutation (206)
  • Chain 'B':
    Compound: Pre-glycoprotein polyprotein GP complex
    Species: Lassa virus [TaxId:11622]
    Gene: GPC, GP-C
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08669
      • engineered mutation (206)
  • Chain 'C':
    Compound: Pre-glycoprotein polyprotein GP complex
    Species: Lassa virus [TaxId:11622]
    Gene: GPC, GP-C
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08669
      • engineered mutation (206)
  • Chain 'D':
    Compound: fab antibody heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6P95
  • Chain 'E':
    Compound: fab antibody light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6P95
  • Chain 'F':
    Compound: fab antibody heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6P95
  • Chain 'G':
    Compound: fab antibody light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6P95
  • Chain 'H':
    Compound: fab antibody heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6P95
  • Chain 'L':
    Compound: fab antibody light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6P95
  • Chain 'a':
    Compound: Pre-glycoprotein polyprotein GP complex
    Species: Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) [TaxId:11622]
    Gene: GPC, GP-C
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08669
      • engineered mutation (69)
      • engineered mutation (72)
      • engineered mutation (100)
  • Chain 'b':
    Compound: Pre-glycoprotein polyprotein GP complex
    Species: Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) [TaxId:11622]
    Gene: GPC, GP-C
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08669
      • engineered mutation (69)
      • engineered mutation (100)
  • Chain 'c':
    Compound: Pre-glycoprotein polyprotein GP complex
    Species: Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) [TaxId:11622]
    Gene: GPC, GP-C
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08669
      • engineered mutation (69)
      • engineered mutation (100)
  • Heterogens: NAG, MAN, FUC, BMA

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6p95A (A:)
mgqivtffqevphvieevmnivlialsvlavlkglynfatcglvglvtflllcgrsctts
lykgvyelqtlelnmetlnmtmplsctknnshhyimvgnetgleltltntsiinhkfcnl
sdahkknlydhalmsiistfhlsipnfnqyeamscdfnggkisvqynlshsyagdaanhc
gtvangvlqtfmrmawggsyialdsgcgnwdcimtsyqyliiqnttwedhcqfsrpspig
ylgllsqrtrdiyisrrrr

    Sequence, based on observed residues (ATOM records):
    >6p95A (A:)
tslykgvyelqtlelnmetlnmtmplsctknnshhyimvgnetgleltltntsiinhkfc
nlsdahkknlydhalmsiistfhlsipnfnqyeamscdfnggkisvqynlshcgtvangv
lqtfmrmawggsyialdsgcgnwdcimtsyqyliiqnttwedhcqfsrpspigylgllsq
rtrdiyis

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6p95B (B:)
mgqivtffqevphvieevmnivlialsvlavlkglynfatcglvglvtflllcgrsctts
lykgvyelqtlelnmetlnmtmplsctknnshhyimvgnetgleltltntsiinhkfcnl
sdahkknlydhalmsiistfhlsipnfnqyeamscdfnggkisvqynlshsyagdaanhc
gtvangvlqtfmrmawggsyialdsgcgnwdcimtsyqyliiqnttwedhcqfsrpspig
ylgllsqrtrdiyisrrrr

    Sequence, based on observed residues (ATOM records):
    >6p95B (B:)
tslykgvyelqtlelnmetlnmtmplsctknnshhyimvgnetgleltltntsiinhkfc
nlsdahkknlydhalmsiistfhlsipnfnamscdfnggkisvqynlcgtvangvlqtfm
rmawggsyialdsgcgnwdcimtsyqyliiqnttwedhcqfsrpspigylgllsqrtrdi
y

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6p95C (C:)
mgqivtffqevphvieevmnivlialsvlavlkglynfatcglvglvtflllcgrsctts
lykgvyelqtlelnmetlnmtmplsctknnshhyimvgnetgleltltntsiinhkfcnl
sdahkknlydhalmsiistfhlsipnfnqyeamscdfnggkisvqynlshsyagdaanhc
gtvangvlqtfmrmawggsyialdsgcgnwdcimtsyqyliiqnttwedhcqfsrpspig
ylgllsqrtrdiyisrrrr

    Sequence, based on observed residues (ATOM records):
    >6p95C (C:)
tslykgvyelqtlelnmetlnmtmplsctknnshhyimvgnetgleltltntsiinhkfc
nlsdahkknlydhalmsiistfhlsipnfnqyeamscdfnggkisvqynlshcgtvangv
lqtfmrmawggsyialdsgcgnwdcimtsyqyliiqnttwedhcqfsrpspigylgllsq
rtrdiyisr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6p95D (D:)
dqvqlqesggglvkaggslrlscaasgfmferyslhwvrqtpgkglewvssisslsgshi
nyadsvkgrftisrdnaknslslqmnslrvedtaiyycardrrsgsspvpldvwgqgttv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkth

    Sequence, based on observed residues (ATOM records):
    >6p95D (D:)
qvqlqesggglvkaggslrlscaasgfmferyslhwvrqtpgkglewvssisslsgshin
yadsvkgrftisrdnaknslslqmnslrvedtaiyycardrrsgsspvpldvwgqgttvt
vssastkgpsvfplapgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6p95E (E:)
dlpvltqpasvsgspgqsitisctgtssdvgaynyvswyqqhpgkapkliiyevkirpsg
vsnrfsgsksgntasltisglqaedeadyfcssystnspwvfgggtkvtvlrqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6p95E (E:)
lpvltqpasvsgspgqsitisctgtssdvgaynyvswyqqhpgkapkliiyevkirpsgv
snrfsgsksgntasltisglqaedeadyfcssystnspwvfgggtkvtvlrqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvap

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6p95F (F:)
dqvqlqesggglvkaggslrlscaasgfmferyslhwvrqtpgkglewvssisslsgshi
nyadsvkgrftisrdnaknslslqmnslrvedtaiyycardrrsgsspvpldvwgqgttv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkth

    Sequence, based on observed residues (ATOM records):
    >6p95F (F:)
qvqlqesggglvkaggslrlscaasgfmferyslhwvrqtpgkglewvssisslsgshin
yadsvkgrftisrdnaknslslqmnslrvedtaiyycardrrsgsspvpldvwgqgttvt
vssastkgpsvfplapgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6p95G (G:)
dlpvltqpasvsgspgqsitisctgtssdvgaynyvswyqqhpgkapkliiyevkirpsg
vsnrfsgsksgntasltisglqaedeadyfcssystnspwvfgggtkvtvlrqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6p95G (G:)
pvltqpasvsgspgqsitisctgtssdvgaynyvswyqqhpgkapkliiyevkirpsgvs
nrfsgsksgntasltisglqaedeadyfcssystnspwvfgggtkvtvlrqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvapt

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6p95H (H:)
dqvqlqesggglvkaggslrlscaasgfmferyslhwvrqtpgkglewvssisslsgshi
nyadsvkgrftisrdnaknslslqmnslrvedtaiyycardrrsgsspvpldvwgqgttv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkth

    Sequence, based on observed residues (ATOM records):
    >6p95H (H:)
qvqlqesggglvkaggslrlscaasgfmferyslhwvrqtpgkglewvssisslsgshin
yadsvkgrftisrdnaknslslqmnslrvedtaiyycardrrsgsspvpldvwgqgttvt
vssastkgpsvfplapggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6p95L (L:)
dlpvltqpasvsgspgqsitisctgtssdvgaynyvswyqqhpgkapkliiyevkirpsg
vsnrfsgsksgntasltisglqaedeadyfcssystnspwvfgggtkvtvlrqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6p95L (L:)
pvltqpasvsgspgqsitisctgtssdvgaynyvswyqqhpgkapkliiyevkirpsgvs
nrfsgsksgntasltisglqaedeadyfcssystnspwvfgggtkvtvlrqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvapt

  • Chain 'a':
    Sequence, based on SEQRES records:
    >6p95a (a:)
gtftwtlsdsegkdtpggycltrwmlieaelkcfgntavakcnekhdeefcdmlrlfdfn
kqaiqrlkapaqtsiqlinkavnalindqlimknhlrdimcipycnyskywylnhtttgr
tslpkcwlvsngsylnethfsddieqqadnmitemlqkeymerqgktplglvdlevdddd

    Sequence, based on observed residues (ATOM records):
    >6p95a (a:)
ftwtlsdsegkdtpggycltrwmlieaelkcfgntavakcnekhdeefcdmlrlfdfnkq
aiqrlkaptsiqlinkavnalindqlimknhlrdimcipycnyskywylnhtttgrtslp
kcwlvsngsylnethfsddieqqadnmitemlq

  • Chain 'b':
    Sequence, based on SEQRES records:
    >6p95b (b:)
gtftwtlsdsegkdtpggycltrwmlieaelkcfgntavakcnekhdeefcdmlrlfdfn
kqaiqrlkapaqtsiqlinkavnalindqlimknhlrdimcipycnyskywylnhtttgr
tslpkcwlvsngsylnethfsddieqqadnmitemlqkeymerqgktplglvdlevdddd

    Sequence, based on observed residues (ATOM records):
    >6p95b (b:)
tftwtlpggycltrwmlieaelkcfgntavakcnekhdeefcdmlrlfdfnkqaiqrlka
psiqlinkavnalindqlimknhlrdimcipycnyskywylnhtttgrtslpkcwlvsng
sylnethfsddieqqadnmitemlq

  • Chain 'c':
    Sequence, based on SEQRES records:
    >6p95c (c:)
gtftwtlsdsegkdtpggycltrwmlieaelkcfgntavakcnekhdeefcdmlrlfdfn
kqaiqrlkapaqtsiqlinkavnalindqlimknhlrdimcipycnyskywylnhtttgr
tslpkcwlvsngsylnethfsddieqqadnmitemlqkeymerqgktplglvdlevdddd

    Sequence, based on observed residues (ATOM records):
    >6p95c (c:)
ftwtlskdtpggycltrwmlieaelkcfgntavakcnekhdeefcdmlrlfdfnkqaiqr
lkapsiqlinkavnalindqlimknhlrdimcipycnyskywylnhtttgrtslpkcwlv
sngsylnethfsddieqqadnmitemlqkeym