PDB entry 6p8x
View 6p8x on RCSB PDB site
Description: Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.
Class: SIGNALING PROTEIN/Inhibitor
Keywords: Inhibitor, GTPase, SIGNALING PROTEIN, SIGNALING PROTEIN-Inhibitor complex
Deposited on
2019-06-08, released
2019-08-28
The last revision prior to the SCOPe 2.07 freeze date was dated
2019-08-28, with a file datestamp of
2019-08-23.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: N/A
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116
- variant (25)
- engineered mutation (64)
- engineered mutation (93)
- engineered mutation (131)
Domains in SCOPe 2.07: d6p8xa_ - Chain 'B':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116
- variant (25)
- engineered mutation (64)
- engineered mutation (93)
- engineered mutation (131)
Domains in SCOPe 2.07: d6p8xb_ - Chain 'C':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (14-End)
- variant (25)
- engineered mutation (64)
- engineered mutation (93)
- engineered mutation (131)
Domains in SCOPe 2.07: d6p8xc_ - Chain 'D':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (14-End)
- variant (25)
- engineered mutation (64)
- engineered mutation (93)
- engineered mutation (131)
Domains in SCOPe 2.07: d6p8xd_ - Heterogens: O5V, CA, GDP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6p8xA (A:)
mkhhhhhhhdevdgmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvi
dgetslldildtagqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkds
edvpmvlvgnksdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh
kek
Sequence, based on observed residues (ATOM records): (download)
>6p8xA (A:)
teyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtagq
eeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlp
srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6p8xB (B:)
mkhhhhhhhdevdgmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvi
dgetslldildtagqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkds
edvpmvlvgnksdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh
kek
Sequence, based on observed residues (ATOM records): (download)
>6p8xB (B:)
teyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtagq
eeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlp
srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
- Chain 'C':
Sequence, based on SEQRES records: (download)
>6p8xC (C:)
mkhhhhhhhdevdgmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvi
dgetslldildtagqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkds
edvpmvlvgnksdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh
kek
Sequence, based on observed residues (ATOM records): (download)
>6p8xC (C:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtag
qeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
- Chain 'D':
Sequence, based on SEQRES records: (download)
>6p8xD (D:)
mkhhhhhhhdevdgmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvi
dgetslldildtagqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkds
edvpmvlvgnksdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh
kek
Sequence, based on observed residues (ATOM records): (download)
>6p8xD (D:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtag
qeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk