PDB entry 6p8w

View 6p8w on RCSB PDB site
Description: Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.
Class: SIGNALING PROTEIN/Inhibitor
Keywords: Inhibitor, GTPase, SIGNALING PROTEIN, SIGNALING PROTEIN-Inhibitor complex
Deposited on 2019-06-08, released 2019-08-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-08-28, with a file datestamp of 2019-08-23.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (14-End)
      • expression tag (13)
      • variant (25)
      • engineered mutation (64)
      • engineered mutation (93)
      • engineered mutation (131)
    Domains in SCOPe 2.07: d6p8wa1, d6p8wa2
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (14-End)
      • expression tag (13)
      • variant (25)
      • engineered mutation (64)
      • engineered mutation (93)
      • engineered mutation (131)
    Domains in SCOPe 2.07: d6p8wb1, d6p8wb2
  • Heterogens: O67, CA, GDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6p8wA (A:)
mkhhhhhhhdevdgmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvi
dgetslldildtagqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkds
edvpmvlvgnksdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh
kek

    Sequence, based on observed residues (ATOM records): (download) 
    >6p8wA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6p8wB (B:)
mkhhhhhhhdevdgmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvi
dgetslldildtagqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkds
edvpmvlvgnksdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh
kek

    Sequence, based on observed residues (ATOM records): (download) 
    >6p8wB (B:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk