PDB entry 6p8g
View 6p8g on RCSB PDB site
Description: Crystal structure of CDK4 in complex with CyclinD1 and P27
Class: cell cycle, transferase
Keywords: Cyclin-dependent kinase, kinase inhibitor, CELL CYCLE, transferase
Deposited on
2019-06-07, released
2019-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-12-25, with a file datestamp of
2019-12-20.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: g1/s-specific cyclin-d1
Species: Homo sapiens [TaxId:9606]
Gene: CCND1, BCL1, PRAD1
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: cyclin-dependent kinase 4
Species: Homo sapiens [TaxId:9606]
Gene: CDK4
Database cross-references and differences (RAF-indexed):
- Uniprot P11802
- engineered mutation (44-45)
Domains in SCOPe 2.08: d6p8gb_ - Chain 'C':
Compound: Cyclin-dependent kinase inhibitor 1B
Species: Homo sapiens [TaxId:9606]
Gene: CDKN1B, KIP1
Database cross-references and differences (RAF-indexed):
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6p8gB (B:)
gefatsryepvaeigvgaygtvykardphsghfvalksvrvpngeeglpistvrevallr
rleafehpnvvrlmdvcatsrtdreikvtlvfehvdqdlrtyldkapppglpaetikdlm
rqflrgldflhancivhrdlkpenilvtsggtvkladfglariysyqmaltpvvvtlwyr
apevllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprd
vslprgafpprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkdegn
pe
Sequence, based on observed residues (ATOM records): (download)
>6p8gB (B:)
gtvykardghfvalksvrvpngeeglpistvrevallrrleafehpnvvrlmdvcatsre
ikvtlvfehvdqdlrtyldkapppglpaetikdlmrqflrgldflhancivhrdlkpeni
lvtsggtvkladfglvtlwyrapevllqstyatpvdmwsvgcifaemfrrkplfcgnsea
dqlgkifdliglppeddwprdvslprgafpprgprpvqsvvpemeesgaqlllemltfnp
hkrisafralqhsylhkde
- Chain 'C':
No sequence available.