PDB entry 6p1l

View 6p1l on RCSB PDB site
Description: Crystal structure of EGFR in complex with EAI045
Class: TRANSFERASE/TRANSFERASE Inhibitor
Keywords: egfr, allosteric inhibitor, TRANSFERASE, TRANSFERASE-TRANSFERASE Inhibitor complex
Deposited on 2019-05-20, released 2019-12-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (94)
      • engineered mutation (252)
    Domains in SCOPe 2.08: d6p1la_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (94)
      • engineered mutation (252)
    Domains in SCOPe 2.08: d6p1lb_
  • Chain 'C':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (94)
      • engineered mutation (252)
    Domains in SCOPe 2.08: d6p1lc_
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (94)
      • engineered mutation (252)
    Domains in SCOPe 2.08: d6p1ld_
  • Heterogens: 9LL, MG, ANP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6p1lA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6p1lA (A:)
qallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreapkankeilde
ayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglvpikwmalesilhriythqsdvws
ygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsrp
kfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6p1lB (B:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6p1lB (B:)
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakvpikwmalesilhriythqsd
vwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidad
srpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6p1lC (C:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6p1lC (C:)
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelrnkeildeayvmas
vdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiakgmnyl
edrrlvhrdlaarnvlvktpqhvkitdfglvpikwmalesilhriythqsdvwsygvtvw
elmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsrpkfreli
iefskmardpqrylviqgdermhlpsptdsnfyralmdee

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6p1lD (D:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6p1lD (D:)
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsr
pkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmdvvdade