PDB entry 6p1d

View 6p1d on RCSB PDB site
Description: Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor
Class: Transferase/Transferase Inhibitor
Keywords: EGFR, Cancer, Inhibitor, SIGNALING PROTEIN, Transferase-Transferase Inhibitor complex
Deposited on 2019-05-19, released 2019-12-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • conflict (94)
      • conflict (252)
    Domains in SCOPe 2.08: d6p1da_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • conflict (94)
      • conflict (252)
    Domains in SCOPe 2.08: d6p1db_
  • Chain 'C':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • conflict (94)
      • conflict (252)
    Domains in SCOPe 2.08: d6p1dc_
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • conflict (94)
      • conflict (252)
    Domains in SCOPe 2.08: d6p1dd_
  • Heterogens: NQ1, ANP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6p1dA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6p1dA (A:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglaklkvpikwmalesilhriyt
hqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwm
idadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvd
adeylipqq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6p1dB (B:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6p1dB (B:)
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgvpikwmalesilhriyth
qsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmi
dadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvda

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6p1dC (C:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6p1dC (C:)
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllvpikwmalesilhriythq
sdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmid
adsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeed

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6p1dD (D:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6p1dD (D:)
qallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeil
deayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvq
iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllvpikwmalesilhriyth
qsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmi
dadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmd