PDB entry 6p14

View 6p14 on RCSB PDB site
Description: Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor (crystal form B)
Class: isomerase/isomerase inhibitor
Keywords: inhibitor, complex, AAA protein, ISOMERASE-ISOMERASE INHIBITOR complex
Deposited on 2019-05-17, released 2019-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spastin
    Species: Drosophila melanogaster [TaxId:7227]
    Gene: spas, CG5977
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I0P1
      • engineered mutation (247)
    Domains in SCOPe 2.08: d6p14a_
  • Heterogens: NKY, MPD, SO4, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6p14A (A:)
gpsgsgastpvvsvkgveqklvqlildeiveggakvewtdiagqdvakqalqemvilpsv
rpelftglrapakglllfgppgngktllaravatecsatflnisaasltskyvgdgeklv
ralfavarhmqpsiifidevdsllserssseheasrrlkteflvefdglpgnpdgdrivv
laatnrpqeldeaalrrftkrvyvslpdeqtrelllnrllqkqgspldtealrrlakitd
gysgsdlaalakdaalepirelnveqvkcldisamraiteqdfhsslkrirrsvapqsln
syekwsqdygditi

    Sequence, based on observed residues (ATOM records): (download) 
    >6p14A (A:)
vvsvkeqklvqlildeiveggakvewtdiagqdvakqalqemvilpsvrpelftglrapa
kglllfgppgngktllaravatecsatflnisklvralfavarhmqpsiifidevdslrl
kteflvefdgdrivvlaatnrpqeldeaalrrftkrvyvslpdeqtrelllnrllqkqgs
pldtealrrlakitdgysgsdlaalakdaalepirelnveqvkcldisamraiteqdfhs
slkrirrsvapqslnsyekwsqdyg