PDB entry 6oz2

View 6oz2 on RCSB PDB site
Description: Crystal structure of the broadly neutralizing antibody N49P6 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core.
Class: immune system
Keywords: hiv-1, vrc01-class antibody, cd4 binding site, clade a/e 93th057 gp120, viral protein-immune system complex, n49p6, immune system
Deposited on 2019-05-15, released 2020-08-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'G':
    Compound: clade A/E 93TH057 HIV-1 gp120 core
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: HIV-1 ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0M3KKW9 (2-End)
      • expression tag (1)
      • engineered mutation (243)
  • Chain 'H':
    Compound: N49P6 antibody Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OZ2 (0-228)
    Domains in SCOPe 2.08: d6oz2h_
  • Chain 'L':
    Compound: N49P6 antibody Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OZ2
    Domains in SCOPe 2.08: d6oz2l1, d6oz2l2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6oz2H (H:)
aglmqsgavmknsgasvrvscqadgydfidyvihwfrqrrgeglewlgwmnpsgggtnyp
rpfqgkvtmtrdtstetayldvrgltyddtavyycvrdrangsgrrrfesvnwfldlwgr
gtqitvvsastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

    Sequence, based on observed residues (ATOM records): (download) 
    >6oz2H (H:)
aglmqsgavmknsgasvrvscqadgydfidyvihwfrqrrgeglewlgwmnpsgggtnyp
rpfqgkvtmtrdtstetayldvrgltyddtavyycvrdrangsgrrrfesvnwfldlwgr
gtqitvvsastkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6oz2L (L:)
qsaltqprsvsaspgqsvtisctgthnyvswcqqkpgqapklliydfnkrpsgvsdrfsg
stsgntasltisglqaddeghyfcwafenigggtkltvlgqpkaapsvtlfppsseelqa
nkatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltpeqwks
hrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6oz2L (L:)
altqprsvsaspgqsvtisctgthnyvswcqqkpgqapklliydfnkrpsgvsdrfsgst
sgntasltisglqaddeghyfcwafenigggtkltvlgqpkaapsvtlfppsseelqank
atlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltpeqwkshr
syscqvthegstvektvapt