PDB entry 6owt

View 6owt on RCSB PDB site
Description: structure of sivsmm nef and smm tetherin bound to the clathrin adaptor ap-2 complex
Deposited on 2019-05-10, released 2019-09-25
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: EM
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.06 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: AP-2 complex subunit alpha
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Ap2a2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: ap-2 complex subunit beta
    Species: Rattus norvegicus [TaxId:10116]
    Gene: AP2B1, CLAPB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: Adaptor protein complex AP-2, mu1
    Species: Mus musculus [TaxId:10090]
    Gene: Ap2m1
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Tetherin,Protein Nef
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: nef
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: ap-2 complex subunit sigma
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Ap2s1, Ap17, Claps2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62744 (0-End)
      • engineered mutation (96)
      • engineered mutation (98)
  • Chain 'T':
    Compound: Tetherin,Protein Nef
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: nef
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6owtA (A:)
mpavskgegmrglavfisdirnckskeaeikrinkelanirskfkgdkaldgyskkkyvc
kllfifllghdidfghmeavnllssnrytekqigylfisvlvnsnselirlinnaikndl
asrnptfmglalhcianvgsremaeafageipkilvagdtmdsvkqsaalcllrlyrtsp
dlvpmgdwtsrvvhllndqhlgvvtaatslittlaqknpeefktsvslavsrlsrivtsa
stdlqdytyyfvpapwlsvkllrllqcypppedpavrgrltecletilnkaqeppkskkv
qhsnaknavlfeaisliihhdsepnllvracnqlgqflqhretnlrylalesmctlasse
fsheavkthietvinalkterdvsvrqravdllyamcdrsnaqqivaemlsyletadysi
reeivlkvailaekyavdytwyvdtilnliriagdyvseevwyrviqivinrddvqgyaa
ktvfealqapachenlvkvggyilgefgnliagdprsspliqfnllhskfhlcsvptral
llstyikfvnlfpevkatiqdvlrsdsqlknadvelqqraveylrlstvastdilatvle
emppfperessilaklkkkkgpstvtdleetkrersidvnggpepvpastsaastpspsa
dllglgavppaptgppptsgggllvdvfsdsasavaplapgsednfarfvcknngvlfen
qllqiglksefrqnlgrmfifygnktstqflnftptlicaddlqtnlnlqtkpvdptvdg
gaqvqqvvniecisdfteapvlniqfryggtfqnvsvklpitlnkffqptemasqdffqr
wkqlsnpqqevqnifkakhpmdteitkakiigfgsalleevdpnpanfvgagiihtkttq
igcllrlepnlqaqmyrltlrtskdtvsqrlcellseqf

    Sequence, based on observed residues (ATOM records):
    >6owtA (A:)
krinkelanirskfkgdkaldgyskkkyvckllfifllghdidfghmeavnllssnryte
kqigylfisvlvnsnselirlinnaikndlasrnptfmglalhcianvgsremaeafage
ipkilvagdtmdsvkqsaalcllrlyrtspdlvpmgdwtsrvvhllndqhlgvvtaatsl
ittlaqknpeefktsvslavsrlsrivtsastdlqdytyyfvpapwlsvkllrllqcypp
pedpavrgrltecletilnkaqeppkskkvqhsnaknavlfeaisliihhdsepnllvra
cnqlgqflqhretnlrylalesmctlassefsheavkthietvinalkterdvsvrqrav
dllyamcdrsnaqqivaemlsyletadysireeivlkvailaekyavdytwyvdtilnli
riagdyvseevwyrviqivinrddvqgyaaktvfealqapachenlvkvggyilgefgnl
iagdprsspliqfnllhskfhlcsvptralllstyikfvnlfpevkatiqdvlrsdsqlk
nadvelqqraveylrlstvastdilatvleemppfperessilaklkkkk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6owtB (B:)
mtdskyfttnkkgeifelkaelnnekkekrkeavkkviaamtvgkdvsslfpdvvncmqt
dnlelkklvylylmnyaksqpdmaimavnsfvkdcedpnpliralavrtmgcirvdkite
ylceplrkclkdedpyvrktaavcvaklhdinaqmvedqgfldslrdliadsnpmvvana
vaalseiseshpnsnlldlnpqninklltalnectewgqifildclsnynpkddreaqsi
cervtprlshansavvlsavkvlmkflellpkdsdyynmllkklapplvtllsgepevqy
valrninlivqkrpeilkqeikvffvkyndpiyvklekldimirlasqaniaqvlaelke
yatevdvdfvrkavraigrcaikveqsaercvstlldliqtkvnyvvqeaivvirdifrk
ypnkyesiiatlcenldsldepdaraamiwivgeyaeridnadellesflegfhdestqv
qltlltaivklflkkpsetqelvqqvlslatqdsdnpdlrdrgyiywrllstdpvtakev
vlsekpliseetdlieptlldelichigslasvyhkppnafvegshgihrk

    Sequence, based on observed residues (ATOM records):
    >6owtB (B:)
kyfttnkkgeifelkaelnnekkekrkeavkkviaamtvgkdvsslfpdvvncmqtdnle
lkklvylylmnyaksqpdmaimavnsfvkdcedpnpliralavrtmgcirvdkiteylce
plrkclkdedpyvrktaavcvaklhdinaqmvedqgfldslrdliadsnpmvvanavaal
seiseshpnsnlldlnpqninklltalnectewgqifildclsnynpkddreaqsicerv
tprlshansavvlsavkvlmkflellpkdsdyynmllkklapplvtllsgepevqyvalr
ninlivqkrpeilkqeikvffvkyndpiyvklekldimirlasqaniaqvlaelkeyate
vdvdfvrkavraigrcaikveqsaercvstlldliqtkvnyvvqeaivvirdifrkypnk
yesiiatlcenldsldepdaraamiwivgeyaeridnadellesflegfhdestqvqltl
ltaivklflkkpsetqelvqqvlslatqdsdnpdlrdrgyiywrllstdpvtakevvlse
kpliseetdlieptlldelichigslasvyhkppnafv

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6owtM (M:)
migglfiynhkgevlisrvyrddigrnavdafrvnviharqqvrspvtniartsffhvkr
sniwlaavtkqnvnaamvfeflykmcdvmaayfgkiseeniknnfvliyelldeildfgy
pqnsetgalktfitqqgiksq

    Sequence, based on observed residues (ATOM records):
    >6owtM (M:)
migglfiynhkgevlisrvyrddigrnavdafrvnviharqqvrspvtniartsffhvkr
sniwlaavtkqnvnaamvfeflykmcdvmaayfgkiseeniknnfvliyelldeildfgy
pqns

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6owtN (N:)
ilydysrmpmgdiwkedgdkrskgsdeasegsgmggvtskkqskrrqglrerllqarget
dgysrsrgelgkgwnlpsaegqgyseeqfmntpwrnparegeklkyrqqnmddvddddde
lvgvavhpkvplramsyklaidmshfikekgglegiyysdrrhrildiylekeegiipdw
qnytsgpgvryplffgwlwklvpvnvsdeaqedethclvhpaqtsqwddpwgevlawkfd
pklaytyeafirypeefgndsglskeevkrrltar

    Sequence, based on observed residues (ATOM records):
    >6owtN (N:)
glrerllqargramsyklaidmshfikekgglegiyysdrrhrildiylekeegiipdwq
nytsgpgvryplffgwlwklvpvnvsdeaqedethclvhpaqtsqwddpwgevlawkfdp
klaytyeafiryp

  • Chain 'S':
    Sequence, based on SEQRES records:
    >6owtS (S:)
mirfiliqnragktrlakwymqfdddekqklieevhavvtvrdakhtnfvefrnfkiiyr
ryaglyfcicvdvndnnlayleaihnfvevlneyfhcvseldlvfnfykvytvvdemfla
geiretsqtkvlkqllmlqsle

    Sequence, based on observed residues (ATOM records):
    >6owtS (S:)
mirfiliqnragktrlakwymqfdddekqklieevhavvtvrdakhtnfvefrnfkiiyr
ryaglyfcicvdvndnnlayleaihnfvevlneyfhcvseldlvfnfykvytvvdemfla
geiretsqtkvlkqllmlqs

  • Chain 'T':
    Sequence, based on SEQRES records:
    >6owtT (T:)
ilydysrmpmgdiwkedgdkrskgsdeasegsgmggvtskkqskrrqglrerllqarget
dgysrsrgelgkgwnlpsaegqgyseeqfmntpwrnparegeklkyrqqnmddvddddde
lvgvavhpkvplramsyklaidmshfikekgglegiyysdrrhrildiylekeegiipdw
qnytsgpgvryplffgwlwklvpvnvsdeaqedethclvhpaqtsqwddpwgevlawkfd
pklaytyeafirypeefgndsglskeevkrrltar

    Sequence, based on observed residues (ATOM records):
    >6owtT (T:)
mpmgdiwked