PDB entry 6osv

View 6osv on RCSB PDB site
Description: Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Class: immune sytem/transferase
Keywords: Single chain Fv, ScFv, Antibody, ROR2, Kringle domain, receptor tyrosine kinase-like orphan receptor, Phage display, IMMUNE SYSTEM, immune sytem-transferase complex
Deposited on 2019-05-02, released 2020-04-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-05-13, with a file datestamp of 2020-05-08.
Experiment type: XRAY
Resolution: 1.34 Å
R-factor: N/A
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Antibody heavy chain variable region
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OSV (0-End)
    Domains in SCOPe 2.08: d6osvh_
  • Chain 'K':
    Compound: tyrosine-protein kinase transmembrane receptor ror2
    Species: Homo sapiens [TaxId:9606]
    Gene: ROR2, NTRKR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6osvk_
  • Chain 'L':
    Compound: Antibody light chain variable region
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OSV (0-110)
    Domains in SCOPe 2.08: d6osvl_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6osvH (H:)
mvqlvesggglvqpggslrlscaasgftfssygvtwvrqapgkglewvsyintagntyya
swaksrftisrdnaknslylqmnslraedtavyycarddrwslniwgqgtlvtvssgggg
sggggs

    Sequence, based on observed residues (ATOM records): (download) 
    >6osvH (H:)
mvqlvesggglvqpggslrlscaasgftfssygvtwvrqapgkglewvsyintagntyya
swaksrftisrdnaknslylqmnslraedtavyycarddrwslniwgqgtlvtvssggg

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6osvK (K:)
mgshhhhhhsvprgshmhqcyngsgmdyrgtasttksghqcqpwalqhphshhlsstdfp
elggghaycrnpggqmegpwcftqnknvrmelcdvpsc

    Sequence, based on observed residues (ATOM records): (download) 
    >6osvK (K:)
hqcyngsgmdyrgtasttksghqcqpwalqhphshhlsstdfpelggghaycrnpggqme
gpwcftqnknvrmelcdvpsc

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6osvL (L:)
sdpmltqspsslsasvgdrvtitcqasqsissdlswyqqkpgkapklliyqastlasgvp
srfkgsgygteytltisslqpedfatyyclggyadasyrtafgggtkleik