PDB entry 6osa

View 6osa on RCSB PDB site
Description: human neurotensin receptor 1 (hntsr1) - gi1 protein complex in non- canonical conformation (nc state)
Deposited on 2019-05-01, released 2019-07-10
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: EM
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAI1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: jmv449
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OSA (0-5)
  • Chain 'R':
    Compound: Neurotensin receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NTSR1, NTRR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30989
      • engineered mutation (104)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6osaA (A:)
mgctlsaedkaaverskmidrnlredgekaarevkllllgagesgkstivkqmkiiheag
yseeeckqykavvysntiqsiiaiiramgrlkidfgdsaraddarqlfvlagaaeegfmt
aelagvikrlwkdsgvqacfnrsreyqlndsaayylndldriaqpnyiptqqdvlrtrvk
ttgivethftfkdlhfkmfdvggqrserkkwihcfegvtaiifcvalsdydlvlaedeem
nrmhesmklfdsicnnkwftdtsiilflnkkdlfeekikksplticypeyagsntyeeaa
ayiqcqfedlnkrkdtkeiythftcatdtknvqfvfdavtdviiknnlkdcglf

    Sequence, based on observed residues (ATOM records):
    >6osaA (A:)
tlsaedkaaverskmidrnlredgekaarevkllllgagesgkstivkqmktgivethft
fkdlhfkmfdvggqrserkkwihcfegvtaiifcvalsdydlvlnrmhesmklfdsicnn
kwftdtsiilflnkkdlfeekikksplticypeyagsntyeeaaayiqcqfedlnkrkdt
keiythftcatdtknvqfvfdavtdviiknnlkdcglf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6osaB (B:)
pgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghla
kiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacgg
ldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqq
tttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffp
ngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnv
wdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >6osaB (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6osaC (C:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >6osaC (C:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpf

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >6osaL (L:)
kkpyil

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6osaR (R:)
dykddddamgqpgngsafllapnrshapdhdvenlyfqgqraqagleeallapgfgnasg
naservlaapsseldvntdiyskvlvtavylalfvvgtvgntvtlftlarkkslqslqst
vhyhlgslalsdlltlllampvelynfiwvhhpwafgdagcrgyyflrdactyatalnva
slsverylaichpfkaktlmsrsrtkkfisaiwlasallavpmlftmgeqnrsadgqhag
glvctptihtatvkvviqvntfmsfifpmvvisvlntiiankltvmvrqaaeqgqvctvg
gpgrvqalrhgvrvlravviafvvcwlpyhvrrlmfcyisdeqwtpflydfyhyfymvtn
alfyvsstinpilynlvsanfrhiflatlaclcpvwrrrrkrpafsrkadsvssnhtlss
natretlylevlfqg

    Sequence, based on observed residues (ATOM records):
    >6osaR (R:)
psseldvntdiyskvlvtavylalfvvgtvgntvtlftlarkkslqslqstvhyhlgsla
lsdlltlllampvelynfiwvhhpwafgdagcrgyyflrdactyatalnvaslsveryla
ichpfkaktlmsrsrtkkfisaiwlasallavpmlftmgeqnrsadgqhagglvctptih
tatvkvviqvntfmsfifpmvvisvlntiiankltvmvrqaaeqctvggpgrvqalrhgv
rvlravviafvvcwlpyhvrrlmfcyisdeqwtpflydfyhyfymvtnalfyvsstinpi
lynlvsanfrhiflatlaclc