PDB entry 6opz

View 6opz on RCSB PDB site
Description: HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, I54L, A71V, L76V, V82F, I84V Mutant in complex with darunavir
Class: hydrolase/hydrolase inhibitor
Keywords: HIV, NL4-3 PROTEASE, DRUG RESISTANCE, PROTEASE INHIBITOR, HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2019-04-25, released 2019-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protease NL4-3
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7ZCL2 (0-98)
      • engineered mutation (6)
      • engineered mutation (12)
      • engineered mutation (15)
      • engineered mutation (32)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (53)
      • engineered mutation (75)
      • engineered mutation (81)
      • engineered mutation (83)
    Domains in SCOPe 2.08: d6opza_
  • Chain 'B':
    Compound: Protease NL4-3
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7ZCL2 (0-98)
      • engineered mutation (6)
      • engineered mutation (12)
      • engineered mutation (15)
      • engineered mutation (32)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (53)
      • engineered mutation (75)
      • engineered mutation (81)
      • engineered mutation (83)
    Domains in SCOPe 2.08: d6opzb_
  • Heterogens: 017, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6opzA (A:)
pqitlwkrplvtvkiegqlkealldtgaddtifeemnlpgrwkpiiiggiggflkvrqyd
qilieicghkvigtvvvgptpfnvigrnlltqigctlnf

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6opzB (B:)
pqitlwkrplvtvkiegqlkealldtgaddtifeemnlpgrwkpiiiggiggflkvrqyd
qilieicghkvigtvvvgptpfnvigrnlltqigctlnf