PDB entry 6opw

View 6opw on RCSB PDB site
Description: HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V Mutant in complex with darunavir
Class: hydrolase/hydrolase inhibitor
Keywords: HIV, NL4-3 PROTEASE, DRUG RESISTANCE, PROTEASE INHIBITOR, HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2019-04-25, released 2019-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease NL4-3
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7ZCI0 (0-98)
    • engineered mutation (6)
    • engineered mutation (12)
    • engineered mutation (15)
    • engineered mutation (31-32)
    • engineered mutation (44-45)
    • engineered mutation (70)
    • engineered mutation (81)
  Domains in SCOPe 2.08: d6opwa_
• Chain 'B':
  Compound: Protease NL4-3
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7ZCI0 (0-98)
    • engineered mutation (6)
    • engineered mutation (12)
    • engineered mutation (15)
    • engineered mutation (31-32)
    • engineered mutation (44-45)
    • engineered mutation (70)
    • engineered mutation (81)
  Domains in SCOPe 2.08: d6opwb_
• Heterogens: 017, SO4, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6opwA (A:)
  pqitlwkrplvtvkiegqlkealldtgaddtifeemnlpgrwkpiiiggiggfikvrqyd
  qilieicghkvigtvlvgptpfnvigrnlltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6opwB (B:)
  pqitlwkrplvtvkiegqlkealldtgaddtifeemnlpgrwkpiiiggiggfikvrqyd
  qilieicghkvigtvlvgptpfnvigrnlltqigctlnf