PDB entry 6oou

View 6oou on RCSB PDB site
Description: Crystal structure of HIV-1 Protease NL4-3 L89V Mutant in complex with darunavir
Class: hydrolase/hydrolase inhibitor
Keywords: HIV, NL4-3 PROTEASE, DRUG RESISTANCE, PROTEASE INHIBITOR, HYDROLASE INHIBITOR COMPLEX, HYDROLASE, hydrolase-hydrolase inhibitor complex
Deposited on 2019-04-23, released 2019-08-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.13 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: nl4-3 protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7ZCR0 (0-98)
    • engineered mutation (6)
    • engineered mutation (88)
  Domains in SCOPe 2.08: d6ooua_
• Chain 'B':
  Compound: nl4-3 protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7ZCR0 (0-98)
    • engineered mutation (6)
    • engineered mutation (88)
  Domains in SCOPe 2.08: d6ooub_
• Heterogens: 017, SO4, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6oouA (A:)
  pqitlwkrplvtikiggqlkealldtgaddtvleemnlpgrwkpkmiggiggfikvrqyd
  qilieicghkaigtvlvgptpvniigrnvltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6oouB (B:)
  pqitlwkrplvtikiggqlkealldtgaddtvleemnlpgrwkpkmiggiggfikvrqyd
  qilieicghkaigtvlvgptpvniigrnvltqigctlnf