PDB entry 6onj

View 6onj on RCSB PDB site
Description: Crystal structure of PPARgamma ligand binding domain in complex with TRAP220 peptide and agonist rosiglitazone
Class: transcription/agonist
Keywords: Nuclear receptors, TZDs, Drug design, Therapeutic targets, TRANSCRIPTION, transcription-agonist complex
Deposited on 2019-04-22, released 2020-03-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisome proliferator-activated receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: PPARG, NR1C3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6onja_
  • Chain 'C':
    Compound: Mediator of RNA polymerase II transcription subunit 1, TRAP220 Coactivator Peptide
    Species: Homo sapiens [TaxId:9606]
    Gene: MED1, ARC205, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: BRL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6onjA (A:)
qlnpesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedki
kfkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygv
heiiytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnaleldds
dlaifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdl
rqivtehvqllqvikktetdmslhpllqeiykdly

    Sequence, based on observed residues (ATOM records): (download) 
    >6onjA (A:)
esadlralakhlydsyiksfpltkakarailtspfviydmnslmmgedkikhitplevai
rifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgv
lisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpg
llnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikkt
etdmslhpllqeiykdly

  • Chain 'C':
    No sequence available.