PDB entry 6ol2

View 6ol2 on RCSB PDB site
Description: Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2019-04-15, released 2020-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-15, with a file datestamp of 2020-04-10.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase WNK1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Wnk1, Hsn2, Prkwnk1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JIH7
      • engineered mutation (188)
    Domains in SCOPe 2.08: d6ol2a_
  • Heterogens: MU7, GOL, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ol2A (A:)
qeernqqqddieeletkavgmsndgrflkfdieigrgsfktvykgldtettvevawcelq
drkltkserqrfkeeaemlkglqhpnivrfydswestvkgkkcivlvtelmtsgtlktyl
krfkvmkikvlrswcrqilkglqflhtrtppiihrdlkcdnifitgptgsvkigdlglat
lkrasfakavigtpefmapemyeekydesvdvyafgmcmlematseypysecqnaaqiyr
rvtsgvkpasfdkvaipevkeiiegcirqnkderysikdllnhaffqeet

    Sequence, based on observed residues (ATOM records): (download) 
    >6ol2A (A:)
dieeletkavgmsndgrflkfdieigrgsfktvykgldtettvevawcelqdrkltkser
qrfkeeaemlkglqhpnivrfydswestvkgkkcivlvtelmtsgtlktylkrfkvmkik
vlrswcrqilkglqflhtrtppiihrdlkcdnifitgptgsvkigdlglatlkrasfaka
vigtpefmapemyeekydesvdvyafgmcmlematseypysecqnaaqiyrrvtsgvkpa
sfdkvaipevkeiiegcirqnkderysikdllnhaffqe