PDB entry 6ojs

View 6ojs on RCSB PDB site
Description: crystal structure of ts-dhfr from cryptosporidium hominis in complex with nadph, fdump, mtx and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3- d]pyrimidine-methyl-phenyl-d-glutamic acid
Deposited on 2019-04-12, released 2019-06-19
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 3.21 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Gene: CHUDEA4_4460
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Gene: CHUDEA4_4460
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Gene: CHUDEA4_4460
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Gene: CHUDEA4_4460
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Cryptosporidium hominis [TaxId:237895]
    Gene: CHUDEA4_4460
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NDP, UFP, D96, MTX

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ojsA (A:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records):
    >6ojsA (A:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkl
ksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlengay
renrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekkv
yiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlaklie
tlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgspf
niasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrkv
eniedfkwedieligyypyptikmdmav

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ojsB (B:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records):
    >6ojsB (B:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkl
ksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlengay
renrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekkv
yiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlaklie
tlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgspf
niasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrkv
eniedfkwedieligyypyptikmdmav

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6ojsC (C:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records):
    >6ojsC (C:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkl
ksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlengay
renrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekkv
yiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlaklie
tlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgspf
niasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrkv
eniedfkwedieligyypyptikmdmav

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6ojsD (D:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records):
    >6ojsD (D:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkl
ksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlengay
renrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekkv
yiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlaklie
tlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgspf
niasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrkv
eniedfkwedieligyypyptikmdmav

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6ojsE (E:)
mseknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwd
sigrrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyr
dalkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

    Sequence, based on observed residues (ATOM records):
    >6ojsE (E:)
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqekkl
ksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlengay
renrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekkv
yiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlaklie
tlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgspf
niasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrkv
eniedfkwedieligyypyptikmdmav