PDB entry 6oia

View 6oia on RCSB PDB site
Description: (1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase
Class: transferase
Keywords: Human Ornithine Aminotransferase (hOAT) Mechanism Based Inhibitors Hepatocellular Carcinoma PLP, TRANSFERASE
Deposited on 2019-04-09, released 2019-09-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-01, with a file datestamp of 2020-03-27.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ornithine aminotransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: OAT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6oiaa_
  • Chain 'B':
    Compound: Ornithine aminotransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: OAT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6oiab_
  • Chain 'C':
    Compound: Ornithine aminotransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: OAT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6oiac_
  • Heterogens: MQ4, PLP, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6oiaA (A:)
gpptsddifereykygahnyhplpvalergkgiylwdvegrkyfdflssysavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehgstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6oiaB (B:)
gpptsddifereykygahnyhplpvalergkgiylwdvegrkyfdflssysavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehgstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6oiaC (C:)
gpptsddifereykygahnyhplpvalergkgiylwdvegrkyfdflssysavnqghchp
kivnalksqvdkltltsrafynnvlgeyeeyitklfnyhkvlpmntgveagetacklark
wgytvkgiqkykakivfaagnfwgrtlsaissstdptsydgfgpfmpgfdiipyndlpal
eralqdpnvaafmvepiqgeagvvvpdpgylmgvrelctrhqvlfiadeiqtglartgrw
lavdyenvrpdivllgkalsgglypvsavlcdddimltikpgehgstyggnplgcrvaia
alevleeenlaenadklgiilrnelmklpsdvvtavrgkgllnaiviketkdwdawkvcl
rlrdngllakpthgdiirfapplvikedelresieiinktilsf