SCOPe 2.08: Structural Classification of Proteins

PDB entry 6of8

View 6of8 on RCSB PDB site
Description: Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CamKII-alpha hub domain
Class: transferase
Keywords: CaMKII hub domain, SIGNALING PROTEIN, TRANSFERASE
Deposited on 2019-03-28, released 2019-04-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: CAMK2A, CAMKA, KIAA0968
Database cross-references and differences (RAF-indexed):
- Uniprot Q9UQM7 (4-End)
  - expression tag (1-3)
  - engineered mutation (13-14)
  - engineered mutation (71)
  - engineered mutation (73)
  - engineered mutation (123)
  - engineered mutation (126)
Domains in SCOPe 2.08: d6of8a1, d6of8a2
Chain 'B':
Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: CAMK2A, CAMKA, KIAA0968
Database cross-references and differences (RAF-indexed):
- Uniprot Q9UQM7 (4-End)
  - expression tag (2-3)
  - engineered mutation (13-14)
  - engineered mutation (71)
  - engineered mutation (73)
  - engineered mutation (123)
  - engineered mutation (126)
Domains in SCOPe 2.08: d6of8b1, d6of8b2
Chain 'C':
Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: CAMK2A, CAMKA, KIAA0968
Database cross-references and differences (RAF-indexed):
- Uniprot Q9UQM7 (4-End)
  - expression tag (2-3)
  - engineered mutation (13-14)
  - engineered mutation (71)
  - engineered mutation (73)
  - engineered mutation (123)
  - engineered mutation (126)
Domains in SCOPe 2.08: d6of8c1, d6of8c2
Chain 'D':
Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: CAMK2A, CAMKA, KIAA0968
Database cross-references and differences (RAF-indexed):
- Uniprot Q9UQM7 (4-End)
  - expression tag (2-3)
  - engineered mutation (13-14)
  - engineered mutation (71)
  - engineered mutation (73)
  - engineered mutation (123)
  - engineered mutation (126)
Domains in SCOPe 2.08: d6of8d1, d6of8d2
Chain 'E':
Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: CAMK2A, CAMKA, KIAA0968
Database cross-references and differences (RAF-indexed):
- Uniprot Q9UQM7 (Start-134)
  - engineered mutation (13-14)
  - engineered mutation (71)
  - engineered mutation (73)
  - engineered mutation (123)
  - engineered mutation (126)
Domains in SCOPe 2.08: d6of8e_
Chain 'F':
Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: CAMK2A, CAMKA, KIAA0968
Database cross-references and differences (RAF-indexed):
- Uniprot Q9UQM7
  - engineered mutation (13-14)
  - engineered mutation (71)
  - engineered mutation (73)
  - engineered mutation (123)
  - engineered mutation (126)
Domains in SCOPe 2.08: d6of8f_
Chain 'G':
Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: CAMK2A, CAMKA, KIAA0968
Database cross-references and differences (RAF-indexed):
- Uniprot Q9UQM7 (4-End)
  - expression tag (2-3)
  - engineered mutation (13-14)
  - engineered mutation (71)
  - engineered mutation (73)
  - engineered mutation (123)
  - engineered mutation (126)
Domains in SCOPe 2.08: d6of8g1, d6of8g2
Heterogens: K, GOL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6of8A (A:)
gphmvrkqeiikvnqqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfe
nlwsrnskpvhntmlnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdg
kwqhvhmhrsgapsv