PDB entry 6oel

View 6oel on RCSB PDB site
Description: Engineered Fab bound to IL-4 receptor
Class: immune system
Keywords: cytokine receptor, fab, IMMUNE SYSTEM
Deposited on 2019-03-27, released 2019-08-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: engineered Interleukin-4, RGA variant
    Species: Homo sapiens [TaxId:9606]
    Gene: IL4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05112 (Start-128)
      • engineered mutation (116-117)
      • engineered mutation (120-121)
      • engineered mutation (123-124)
      • engineered mutation (127-128)
    Domains in SCOPe 2.08: d6oela_
  • Chain 'B':
    Compound: Interleukin-4 receptor subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: IL4R, IL4RA, 582J2.1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24394 (4-201)
      • expression tag (3)
    Domains in SCOPe 2.08: d6oelb1, d6oelb2, d6oelb3
  • Chain 'C':
    Compound: Cytokine receptor common subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: IL2RG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6oelc1
  • Chain 'H':
    Compound: engineered Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OEL (0-End)
    Domains in SCOPe 2.08: d6oelh1, d6oelh2
  • Chain 'L':
    Compound: engineered Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OEL (0-End)
    Domains in SCOPe 2.08: d6oell1, d6oell2
  • Heterogens: NAG, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6oelA (A:)
hkcditlqeiiktlnslteqktlcteltvtdifaaskntteketfcraatvlrqfyshhe
kdtrclgataqqfhrhkqlirflkrldrnlwglaglnscpvkeanqstlenflerlrvim
qskwfkcga

    Sequence, based on observed residues (ATOM records): (download) 
    >6oelA (A:)
cditlqeiiktlnslteqktlcteltvtdifaaskntteketfcraatvlrqfyshhekd
trclgataqqfhrhkqlirflkrldrnlwglaglnscpvkeanqstlenflerlrvimqs
kwfkcga

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6oelB (B:)
adpfkvlqeptcvsdymsistcewkmngptncstelrllyqlvfllseahtcipenngga
gcvchllmddvvsadnytldlwagqqllwkgsfkpsehvkprapgnltvhtnvsdtlllt
wsnpyppdnylynhltyavniwsendpadfriynvtylepslriaastlksgisyrarvr
awaqcynttwsewspstkwhns

    Sequence, based on observed residues (ATOM records): (download) 
    >6oelB (B:)
fkvlqeptcvsdymsistcewkmngptncstelrllyqlvfllseahtcipennggagcv
chllmddvvsadnytldlwagqqllwkgsfkpsehvkprapgnltvhtnvsdtllltwsn
pyppdnylynhltyavniwsendpadfriynvtylepslriaastlksgisyrarvrawa
qcynttwsewspstkwhns

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6oelC (C:)
qcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeitsgcqlqkk
eihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqlelnwnnrfln
hclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaqhwsew
shpihwgsn

    Sequence, based on observed residues (ATOM records): (download) 
    >6oelC (C:)
qcfvfnveymnctwlhywyknsdndkvqkcshylftsgcqlqkkeihlyqtfvvqmlklq
nlvipwapenltlhklsesqlelnwnnrflnhclehlvqyrtdwdhswteqsvdyrhkfs
lpsvdgqkrytfrvrsrfnplcgsaqhwsewshpihwgsn

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6oelH (H:)
qvqlqqsgpglvkpsqtlsltcaisgdsvssniatwnwirqspsrglewlgrtyyrskwy
ndyavsvrsrisispdtsknqfslqlnsvtpedtaiyycarfsgwlgtgdcwgqgtlvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvcsrlevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6oelH (H:)
qvqlqqsgpglvkpsqtlsltcaisgdsvssniatwnwirqspsrglewlgrtyyrskwy
ndyavsvrsrisispdtsknqfslqlnsvtpedtaiyycarfsgwlgtgdcwgqgtlvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvcsr

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6oelL (L:)
diqvtqspsslsasvgdrvtitcrasqgistwlawyqqrpgkapklliyaassletgvps
rfsgsgsgtdftltisslqpedfatyycqqsystpwtfgqgtkveikrtvaapsvfifpp
sdsqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgecsrgglevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6oelL (L:)
diqvtqspsslsasvgdrvtitcrasqgistwlawyqqrpgkapklliyaassletgvps
rfsgsgsgtdftltisslqpedfatyycqqsystpwtfgqgtkveikrtvaapsvfifpp
sdsqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge