PDB entry 6oej

View 6oej on RCSB PDB site
Description: crystal structure of the non-neutralizing and adcc-potent antibody c11 in complex with hiv-1 clade a/e gp120
Deposited on 2019-03-27, released 2020-07-15
The last revision was dated 2020-07-15, with a file datestamp of 2020-07-10.
Experiment type: XRAY
Resolution: 3.45 Å
R-factor: N/A
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: clade A/E 93TH057 HIV-1 gp120 core
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: HIV-1 ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0M3KKW9 (13-365)
      • see sequence details (0-12)
      • engineered mutation (49)
      • engineered mutation (254)
      • see sequence details (366-370)
  • Chain 'B':
    Compound: C11 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OEJ (0-End)
  • Chain 'C':
    Compound: C11 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OEJ (0-End)
  • Chain 'G':
    Compound: clade A/E 93TH057 HIV-1 gp120 core
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: HIV-1 ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0M3KKW9 (13-365)
      • see sequence details (0-12)
      • engineered mutation (49)
      • engineered mutation (254)
      • see sequence details (366-370)
  • Chain 'H':
    Compound: C11 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OEJ (0-End)
  • Chain 'L':
    Compound: C11 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6OEJ (0-End)
  • Heterogens: NAG, BMA, FUC

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6oejA (A:)
cdnlwvtvyygvpvwkdadttlfcasdakahetevhnvwathacvptdpcpqeihlenvt
enfnmwknnmveqmqedvislwdqslqpcvkltggsvikqacpkisfdpipihyctpagy
vilkcndknfngtgpcknvssvqcthgikpvvstqlllngslaeeeiiirsenltnnakt
iivhlnksveinctrpsnggsgsggdirkayceingtkwnkvlkqvteklkehfnnktii
fqppsggdleitmhsfncrgeffycnttqlfnntcignetmkgcngtitlpckikqiinm
wqgtgqamyappidgkincvsnitgilltrdgganntsnetfrpgggnikdnwrselyky
kvvqieplgiaptkakrrvvqrekr

    Sequence, based on observed residues (ATOM records):
    >6oejA (A:)
cdnlwvtvyygvpvwkdadttlfcasdhacvptdpcpqeihlenvtenfnmwknnmveqm
qedvislwdqssfdpipihyctpagyvilkcndknfngtgpcknvssvqcthgikpvvst
qlllngslaeeeiiirsenltnnaktiivhlnksveinctrpskayceingtkwnkvlkq
vteklkehfnnktiifqppsggdleitmhsfncrgeffycnttqlfnntcimkgcngtit
lpckikqiinmwqgtgqamyappidgkincvsnitgilltrdgganntsnetfrpgggni
kdnwrselykykvvqieplgia

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6oejB (B:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgrglewvssisntstyiyy
adsvegrftlsrdnaknslylqmnslraedtavyycaranqhfdwllsllggyhyygmdv
wgqgttvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsg
vhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdktht

    Sequence, based on observed residues (ATOM records):
    >6oejB (B:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgrglewvssisntstyiyy
adsvegrftlsrdnaknslylqmnslraedtavyycaranqhfdwllsllggyhyygmdv
wgqgttvtvssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6oejC (C:)
divmtqsplslpvtpgepasiscrssqsllhsngynyldwylqkpgqspqlliylgsnra
sgvpdrfigsgsgtdftlkisrveaedvgvfycmqalqavgfgpgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6oejC (C:)
divmtqsplslpvtpgepasiscrssqsllhsngynyldwylqkpgqspqlliylgsnra
sgvpdrfigsgsgtdftlkisrveaedvgvfycmqalqavgfgpgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6oejG (G:)
cdnlwvtvyygvpvwkdadttlfcasdakahetevhnvwathacvptdpcpqeihlenvt
enfnmwknnmveqmqedvislwdqslqpcvkltggsvikqacpkisfdpipihyctpagy
vilkcndknfngtgpcknvssvqcthgikpvvstqlllngslaeeeiiirsenltnnakt
iivhlnksveinctrpsnggsgsggdirkayceingtkwnkvlkqvteklkehfnnktii
fqppsggdleitmhsfncrgeffycnttqlfnntcignetmkgcngtitlpckikqiinm
wqgtgqamyappidgkincvsnitgilltrdgganntsnetfrpgggnikdnwrselyky
kvvqieplgiaptkakrrvvqrekr

    Sequence, based on observed residues (ATOM records):
    >6oejG (G:)
cdnlwvtvyygvpvwkdadttlfcasdacvptdpcpqeihlenvtenfnmwknnmveqmq
edvislwdqssfdpipihyctpagyvilkcndknfngtgpcknvssvqcthgikpvvstq
lllngslaeeeiiirsenltnnaktiivhlnksveinctrpskayceingtkwnkvlkqv
teklkehfnnktiifqppsggdleitmhsfncrgeffycnttqlfnntcigcngtitlpc
kikqiinmwqgtgqamyappidgkincvsnitgilltrdgganntsnetfrpgggnikdn
wrselykykvvqieplgia

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6oejH (H:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgrglewvssisntstyiyy
adsvegrftlsrdnaknslylqmnslraedtavyycaranqhfdwllsllggyhyygmdv
wgqgttvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsg
vhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdktht

    Sequence, based on observed residues (ATOM records):
    >6oejH (H:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgrglewvssisntstyiyy
adsvegrftlsrdnaknslylqmnslraedtavyycaranqhfdwllsllggyhyygmdv
wgqgttvtvssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6oejL (L:)
divmtqsplslpvtpgepasiscrssqsllhsngynyldwylqkpgqspqlliylgsnra
sgvpdrfigsgsgtdftlkisrveaedvgvfycmqalqavgfgpgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6oejL (L:)
divmtqsplslpvtpgepasiscrssqsllhsngynyldwylqkpgqspqlliylgsnra
sgvpdrfigsgsgtdftlkisrveaedvgvfycmqalqavgfgpgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnr