PDB entry 6oe8

View 6oe8 on RCSB PDB site
Description: The crystal structure of hyper-thermostable AgUricase mutant K12C/E286C
Class: oxidoreductase
Keywords: Uricase, Arthrobacter globiformis, thermostability, disulfide cross-linking, OXIDOREDUCTASE
Deposited on 2019-03-27, released 2019-08-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Uricase
    Species: Arthrobacter globiformis [TaxId:1665]
    Gene: uox
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWQ1 (Start-325)
      • engineered mutation (35)
      • engineered mutation (309)
    Domains in SCOPe 2.08: d6oe8a1, d6oe8a2
  • Chain 'B':
    Compound: Uricase
    Species: Arthrobacter globiformis [TaxId:1665]
    Gene: uox
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWQ1 (Start-325)
      • engineered mutation (35)
      • engineered mutation (309)
    Domains in SCOPe 2.08: d6oe8b1, d6oe8b2
  • Chain 'C':
    Compound: Uricase
    Species: Arthrobacter globiformis [TaxId:1665]
    Gene: uox
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWQ1 (Start-325)
      • engineered mutation (35)
      • engineered mutation (309)
    Domains in SCOPe 2.08: d6oe8c1, d6oe8c2
  • Chain 'D':
    Compound: Uricase
    Species: Arthrobacter globiformis [TaxId:1665]
    Gene: uox
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWQ1 (Start-325)
      • engineered mutation (35)
      • engineered mutation (309)
    Domains in SCOPe 2.08: d6oe8d1, d6oe8d2
  • Heterogens: PG4, PGE, MLI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6oe8A (A:)
masmtggqqmgrgsefmhhhhhhhhtataetstgtcvvlgqnqygkaevrlvkvtrntar
heiqdlnvtsqlrgdfeaahtagdnahvvatdtqkntvyafardgfatteefllrlgkhf
tegfdwvtggrwaaqqffwdrindhdhafsrnksevrtavleisgseqaivagiegltvl
kstgsefhgfprdkyttlqettdrilatdvsarwryntvevdfdavyasvrglllkafae
thslalqqtmyemgraviethpeideikmslpnkhhflvdlqpfgqdnpnevfyaadrpy
glieatiqrcgsradhpiwsniagfc

    Sequence, based on observed residues (ATOM records): (download) 
    >6oe8A (A:)
tcvvlgqnqygkaevrlvkvtrntarheiqdlnvtsqlrgdfeaahtagdnahvvatdtq
kntvyafardgfatteefllrlgkhftegfdwvtggrwaaqqffwdrindhdhafsrnks
evrtavleisgseqaivagiegltvlkstgsefhgfprdkyttlqettdrilatdvsarw
ryntvevdfdavyasvrglllkafaethslalqqtmyemgraviethpeideikmslpnk
hhflvdlqpfgqdnpnevfyaadrpyglieatiqrcgsradhpiwsniagfc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6oe8B (B:)
masmtggqqmgrgsefmhhhhhhhhtataetstgtcvvlgqnqygkaevrlvkvtrntar
heiqdlnvtsqlrgdfeaahtagdnahvvatdtqkntvyafardgfatteefllrlgkhf
tegfdwvtggrwaaqqffwdrindhdhafsrnksevrtavleisgseqaivagiegltvl
kstgsefhgfprdkyttlqettdrilatdvsarwryntvevdfdavyasvrglllkafae
thslalqqtmyemgraviethpeideikmslpnkhhflvdlqpfgqdnpnevfyaadrpy
glieatiqrcgsradhpiwsniagfc

    Sequence, based on observed residues (ATOM records): (download) 
    >6oe8B (B:)
tcvvlgqnqygkaevrlvkvtrntarheiqdlnvtsqlrgdfeaahtagdnahvvatdtq
kntvyafardgfatteefllrlgkhftegfdwvtggrwaaqqffwdrindhdhafsrnks
evrtavleisgseqaivagiegltvlkstgsefhgfprdkyttlqettdrilatdvsarw
ryntvevdfdavyasvrglllkafaethslalqqtmyemgraviethpeideikmslpnk
hhflvdlqpfgqdnpnevfyaadrpyglieatiqrcgsradhpiwsniagfc

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6oe8C (C:)
masmtggqqmgrgsefmhhhhhhhhtataetstgtcvvlgqnqygkaevrlvkvtrntar
heiqdlnvtsqlrgdfeaahtagdnahvvatdtqkntvyafardgfatteefllrlgkhf
tegfdwvtggrwaaqqffwdrindhdhafsrnksevrtavleisgseqaivagiegltvl
kstgsefhgfprdkyttlqettdrilatdvsarwryntvevdfdavyasvrglllkafae
thslalqqtmyemgraviethpeideikmslpnkhhflvdlqpfgqdnpnevfyaadrpy
glieatiqrcgsradhpiwsniagfc

    Sequence, based on observed residues (ATOM records): (download) 
    >6oe8C (C:)
tcvvlgqnqygkaevrlvkvtrntarheiqdlnvtsqlrgdfeaahtagdnahvvatdtq
kntvyafardgfatteefllrlgkhftegfdwvtggrwaaqqffwdrindhdhafsrnks
evrtavleisgseqaivagiegltvlkstgsefhgfprdkyttlqettdrilatdvsarw
ryntvevdfdavyasvrglllkafaethslalqqtmyemgraviethpeideikmslpnk
hhflvdlqpfgqdnpnevfyaadrpyglieatiqrcgsradhpiwsniagfc

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6oe8D (D:)
masmtggqqmgrgsefmhhhhhhhhtataetstgtcvvlgqnqygkaevrlvkvtrntar
heiqdlnvtsqlrgdfeaahtagdnahvvatdtqkntvyafardgfatteefllrlgkhf
tegfdwvtggrwaaqqffwdrindhdhafsrnksevrtavleisgseqaivagiegltvl
kstgsefhgfprdkyttlqettdrilatdvsarwryntvevdfdavyasvrglllkafae
thslalqqtmyemgraviethpeideikmslpnkhhflvdlqpfgqdnpnevfyaadrpy
glieatiqrcgsradhpiwsniagfc

    Sequence, based on observed residues (ATOM records): (download) 
    >6oe8D (D:)
tcvvlgqnqygkaevrlvkvtrntarheiqdlnvtsqlrgdfeaahtagdnahvvatdtq
kntvyafardgfatteefllrlgkhftegfdwvtggrwaaqqffwdrindhdhafsrnks
evrtavleisgseqaivagiegltvlkstgsefhgfprdkyttlqettdrilatdvsarw
ryntvevdfdavyasvrglllkafaethslalqqtmyemgraviethpeideikmslpnk
hhflvdlqpfgqdnpnevfyaadrpyglieatiqrcgsradhpiwsniagfc