PDB entry 6oav

View 6oav on RCSB PDB site
Description: JAK2 JH2 in complex with JAK146
Class: transferase/transferase inhibitor
Keywords: Pseudokinase domain, Inhibitor, Complex, TRANSFERASE, transferase-transferase inhibitor complex
Deposited on 2019-03-18, released 2020-03-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (123)
      • engineered mutation (241)
      • engineered mutation (258)
    Domains in SCOPe 2.08: d6oava_
  • Heterogens: M3A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6oavA (A:)
vfhkirnedlifneslgqgtftkifkgvrrevgdygqlhetevllkvldkahrnysesff
eaasmmsklshkhlvlnygvcvcgdenilvqefvkfgsldtylkknkncinilwklevak
qlaaamhfleentlihgnvcaknillireedrktgnppfiklsdpgisitvlpkdilqer
ipwvppecienpknlnlatdkwsfgttlweicsggdkplsaldsqrklqfyedrhqlpap
kaaelanlinncmdyepdhrpsfraiirdlnslftpdlvprgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6oavA (A:)
fhkirnedlifneslgqgtftkifkgvrrevgdygqlhetevllkvldkahrnysesffe
aasmmsklshkhlvlnygvcvcgdenilvqefvkfgsldtylkknkncinilwklevakq
laaamhfleentlihgnvcaknillireedrktgnppfiklsdpgisitvlpkdilqeri
pwvppecienpknlnlatdkwsfgttlweicsggdkplsaldsqrklqfyedrhqlpapk
aaelanlinncmdyepdhrpsfraiirdlnsl