PDB entry 6o94

View 6o94 on RCSB PDB site
Description: Structure of the IRAK4 kinase domain with compound 17
Class: immune system
Keywords: kinase, IRAK4, IRAK1, IRAK2, IRAK3, IMMUNE SYSTEM
Deposited on 2019-03-13, released 2019-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o94a_
  • Chain 'B':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o94b_
  • Chain 'C':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o94c_
  • Chain 'D':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o94d_
  • Heterogens: CA, LRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6o94A (A:)
mhhhhhhgenlyfqgsvsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykg
yvnnttvavkklaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyv
ympngslldrlscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaf
takisdfglarasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitg
lpavdehrepqllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknk
rpdikkvqqllqemtasgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6o94A (A:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasqtvmts
rivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiede
ektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6o94B (B:)
mhhhhhhgenlyfqgsvsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykg
yvnnttvavkklaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyv
ympngslldrlscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaf
takisdfglarasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitg
lpavdehrepqllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknk
rpdikkvqqllqemtasgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6o94B (B:)
dtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdi
tteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtp
plswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasqtvmt
srivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeied
eektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6o94C (C:)
mhhhhhhgenlyfqgsvsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykg
yvnnttvavkklaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyv
ympngslldrlscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaf
takisdfglarasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitg
lpavdehrepqllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknk
rpdikkvqqllqemtasgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6o94C (C:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkltteelkq
qfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplswhmr
ckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasqtvmtsrivgtt
aymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektied
yidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6o94D (D:)
mhhhhhhgenlyfqgsvsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykg
yvnnttvavkklaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyv
ympngslldrlscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaf
takisdfglarasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitg
lpavdehrepqllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknk
rpdikkvqqllqemtasgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6o94D (D:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkltteelkq
qfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplswhmr
ckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarastvmtsrivgtta
ymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektiedy
idkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt