PDB entry 6o8u

View 6o8u on RCSB PDB site
Description: Crystal structure of IRAK4 in complex with compound 23
Class: transferase/transferase inhibitor
Keywords: kinase, inhibitor, inflammation, lupus, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2019-03-12, released 2019-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o8ua_
  • Chain 'B':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o8ub_
  • Chain 'C':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o8uc_
  • Chain 'D':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o8ud_
  • Heterogens: LS7, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6o8uA (A:)
svsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaam
vditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscld
gtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasek
faqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllld
ikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt
asgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6o8uA (A:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkltteelkqq
fdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplswhmrc
kiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasvmtsrivgttaym
apealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektiedyid
kkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6o8uB (B:)
svsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaam
vditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscld
gtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasek
faqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllld
ikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt
asgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6o8uB (B:)
vsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklttee
lkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplsw
hmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasmtsrivgtt
aymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektied
yidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6o8uC (C:)
svsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaam
vditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscld
gtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasek
faqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllld
ikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt
asgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6o8uC (C:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasqtvmts
rivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiede
ektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6o8uD (D:)
svsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaam
vditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscld
gtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasek
faqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllld
ikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt
asgns

    Sequence, based on observed residues (ATOM records): (download) 
    >6o8uD (D:)
dtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasvmtsri
vgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeek
tiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt