PDB entry 6o5n

View 6o5n on RCSB PDB site
Description: Tubulin-RB3_SLD-TTL in complex with compound 10ab
Class: cell cycle
Keywords: Microtubule Inhibitor, Colchicine, Cancer, CELL CYCLE
Deposited on 2019-03-04, released 2019-07-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o5na1, d6o5na2
  • Chain 'B':
    Compound: Tubulin beta-2B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o5nb1, d6o5nb2
  • Chain 'C':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o5nc1, d6o5nc2
  • Chain 'D':
    Compound: Tubulin beta-2B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o5nd1, d6o5nd2
  • Chain 'E':
    Compound: Stathmin-4
    Species: Homo sapiens [TaxId:9606]
    Gene: STMN4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6o5ne_
  • Chain 'F':
    Compound: tubulin tyrosine ligase
    Species: Gallus gallus [TaxId:9031]
    Gene: TTL
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1BQ43 (0-377)
      • expression tag (378-379)
    Domains in SCOPe 2.08: d6o5nf1, d6o5nf2, d6o5nf3
  • Heterogens: QW9, GTP, MG, CA, GDP, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6o5nA (A:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegee

    Sequence, based on observed residues (ATOM records): (download) 
    >6o5nA (A:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6o5nB (B:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeeegedea

    Sequence, based on observed residues (ATOM records): (download) 
    >6o5nB (B:)
reivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyvp
railvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvvr
kesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvve
pynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttclr
fpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmma
acdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprgl
kmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvse
yqqyqda

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6o5nC (C:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegee

    Sequence, based on observed residues (ATOM records): (download) 
    >6o5nC (C:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6o5nD (D:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeeegedea

    Sequence, based on observed residues (ATOM records): (download) 
    >6o5nD (D:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfaplltvpeltqqmfdsknmmaacdprhgry
ltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprglkmsatfign
staiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvseyqqyqdata
d

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6o5nE (E:)
madmevielnkctsgqsfevilkppsfdgvpefnaslprrrdpsleeiqkkleaaeerrk
yqeaellkhlaekrehereviqkaieennnfikmakeklaqkmesnkenreahlaamler
lqekdkhaeevrknkelkeeasr

    Sequence, based on observed residues (ATOM records): (download) 
    >6o5nE (E:)
mevielnkctsgqsfevilkppsdpsleeiqkkleaaeerrkyqeaellkhlaekreher
eviqkaieennnfikmakeklaqkmesnkenreahlaamlerlqekdkhaeevrknkelk
e

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6o5nF (F:)
mytfvvrdenssvyaevsrlllatgqwkrlrkdnprfnlmlgernrlpfgrlghepglvq
lvnyyrgadklcrkaslvkliktspelsesctwfpesyviyptnlktpvapaqngirhli
nntrtderevflaaynrrregregnvwiakssagakgegilisseaselldfideqgqvh
viqkylekplllepghrkfdirswvlvdhlyniylyregvlrtssepynsanfqdktchl
tnhciqkeysknygryeegnemffeefnqylmdalnttlensillqikhiirsclmciep
aistkhlhyqsfqlfgfdfmvdeelkvwlievngapacaqklyaelcqgivdvaissvfp
ladtgqktsqptsifiklhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6o5nF (F:)
mytfvvrdenssvyaevsrlllatgqwkrlrkdnprfnlmlgernrlpfgrlghepglvq
lvnyyrgadklcrkaslvkliktspelsesctwfpesyviyptrevflaaynrrregreg
nvwialisseaselldfideqgqvhviqkylekplllepghrkfdirswvlvdhlyniyl
yregvlrtssepynsanfqdktchltnhciqknygryeegnemffeefnqylmdalnttl
ensillqikhiirsclmciepaistkhlhyqsfqlfgfdfmvdeelkvwlievngapaca
qklyaelcqgivdvaissvfplatsifiklhh