PDB entry 6o4w

View 6o4w on RCSB PDB site
Description: Binary complex of native hAChE with Donepezil
Class: hydrolase
Keywords: hydrolase
Deposited on 2019-03-01, released 2019-06-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-07-10, with a file datestamp of 2019-07-05.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6o4wa_
  • Chain 'B':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6o4wb_
  • Heterogens: GOL, E20, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6o4wA (A:)
gplegredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpws
gvvdattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvw
iygggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqr
lalqwvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwa
tvgmgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrf
sfvpvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisra
eflagvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagr
laaqgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlm
rywanfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflp
kllsatdtld

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4wA (A:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvv
dgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagv
rvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqga
rvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanf
artgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6o4wB (B:)
gplegredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpws
gvvdattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvw
iygggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqr
lalqwvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwa
tvgmgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrf
sfvpvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisra
eflagvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagr
laaqgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlm
rywanfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflp
kllsatdtld

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4wB (B:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvv
dgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagv
rvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqga
rvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanf
artgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat