PDB entry 6o4d

View 6o4d on RCSB PDB site
Description: Structure of ALDH7A1 mutant W175A complexed with L-pipecolic acid
Class: oxidoreductase
Keywords: aldehyde dehydrogenase, nad, oxidoreductase, lysine catabolism
Deposited on 2019-02-28, released 2019-07-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-aminoadipic semialdehyde dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH7A1, ATQ1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49419
      • engineered mutation (176)
    Domains in SCOPe 2.07: d6o4da_
  • Chain 'B':
    Compound: Alpha-aminoadipic semialdehyde dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH7A1, ATQ1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49419 (Start-512)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d6o4db_
  • Chain 'C':
    Compound: Alpha-aminoadipic semialdehyde dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH7A1, ATQ1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49419
      • engineered mutation (176)
    Domains in SCOPe 2.07: d6o4dc_
  • Chain 'D':
    Compound: Alpha-aminoadipic semialdehyde dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH7A1, ATQ1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49419 (Start-512)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d6o4dd_
  • Chain 'E':
    Compound: Alpha-aminoadipic semialdehyde dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH7A1, ATQ1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49419 (Start-512)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d6o4de_
  • Chain 'F':
    Compound: Alpha-aminoadipic semialdehyde dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH7A1, ATQ1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49419 (Start-512)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d6o4df_
  • Chain 'G':
    Compound: Alpha-aminoadipic semialdehyde dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH7A1, ATQ1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49419
      • engineered mutation (176)
    Domains in SCOPe 2.07: d6o4dg_
  • Chain 'H':
    Compound: Alpha-aminoadipic semialdehyde dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH7A1, ATQ1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49419 (Start-512)
      • engineered mutation (176)
    Domains in SCOPe 2.07: d6o4dh_
  • Heterogens: 6PC, PGE, PEG, 1PE, PG4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6o4dA (A:)
ghmstllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasva
dyeetvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvge
vqeyvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavyganna
iamicgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakder
vnllsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgta
gqrcttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgave
eakkeggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfa
wnnevkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggr
esgsdawkqymrrstctinyskdlplaqgikfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4dA (A:)
tllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasvadyee
tvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvgevqey
vdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavygannaiami
cgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakdervnll
sftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgtagqrc
ttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgaveeakk
eggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfawnne
vkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggresgs
dawkqymrrstctinyskdlplaqgikf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6o4dB (B:)
ghmstllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasva
dyeetvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvge
vqeyvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavyganna
iamicgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakder
vnllsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgta
gqrcttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgave
eakkeggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfa
wnnevkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggr
esgsdawkqymrrstctinyskdlplaqgikfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4dB (B:)
stllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasvadye
etvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvgevqe
yvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavygannaiam
icgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakdervnl
lsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgtagqr
cttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgaveeak
keggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfawnn
evkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggresg
sdawkqymrrstctinyskdlplaqgikfq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6o4dC (C:)
ghmstllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasva
dyeetvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvge
vqeyvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavyganna
iamicgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakder
vnllsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgta
gqrcttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgave
eakkeggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfa
wnnevkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggr
esgsdawkqymrrstctinyskdlplaqgikfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4dC (C:)
tllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasvadyee
tvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvgevqey
vdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavygannaiami
cgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakdervnll
sftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgtagqrc
ttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgaveeakk
eggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfawnne
vkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggresgs
dawkqymrrstctinyskdlplaqgikf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6o4dD (D:)
ghmstllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasva
dyeetvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvge
vqeyvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavyganna
iamicgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakder
vnllsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgta
gqrcttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgave
eakkeggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfa
wnnevkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggr
esgsdawkqymrrstctinyskdlplaqgikfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4dD (D:)
tllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasvadyee
tvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvgevqey
vdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavygannaiami
cgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakdervnll
sftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgtagqrc
ttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgaveeakk
eggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfawnne
vkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggresgs
dawkqymrrstctinyskdlplaqgikfq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6o4dE (E:)
ghmstllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasva
dyeetvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvge
vqeyvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavyganna
iamicgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakder
vnllsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgta
gqrcttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgave
eakkeggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfa
wnnevkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggr
esgsdawkqymrrstctinyskdlplaqgikfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4dE (E:)
tllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasvadyee
tvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvgevqey
vdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavygannaiami
cgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakdervnll
sftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgtagqrc
ttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgaveeakk
eggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfawnne
vkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggresgs
dawkqymrrstctinyskdlplaqgikfq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6o4dF (F:)
ghmstllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasva
dyeetvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvge
vqeyvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavyganna
iamicgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakder
vnllsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgta
gqrcttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgave
eakkeggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfa
wnnevkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggr
esgsdawkqymrrstctinyskdlplaqgikfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4dF (F:)
tllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasvadyee
tvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvgevqey
vdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavygannaiami
cgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakdervnll
sftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgtagqrc
ttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgaveeakk
eggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfawnne
vkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggresgs
dawkqymrrstctinyskdlplaqgikfq

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6o4dG (G:)
ghmstllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasva
dyeetvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvge
vqeyvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavyganna
iamicgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakder
vnllsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgta
gqrcttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgave
eakkeggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfa
wnnevkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggr
esgsdawkqymrrstctinyskdlplaqgikfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4dG (G:)
tllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasvadyee
tvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvgevqey
vdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavygannaiami
cgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakdervnll
sftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgtagqrc
ttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgaveeakk
eggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfawnne
vkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggresgs
dawkqymrrstctinyskdlplaqgikf

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6o4dH (H:)
ghmstllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasva
dyeetvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvge
vqeyvdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavyganna
iamicgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakder
vnllsftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgta
gqrcttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgave
eakkeggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfa
wnnevkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggr
esgsdawkqymrrstctinyskdlplaqgikfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6o4dH (H:)
tllinqpqyawlkelglreenegvyngswggrgevittycpannepiarvrqasvadyee
tvkkareawkiwadipapkrgeivrqigdalrekiqvlgslvslemgkilvegvgevqey
vdicdyavglsrmiggpilpsersghalieqwnpvglvgiitafnfpvavygannaiami
cgnvclwkgapttslisvavtkiiakvlednklpgaicsltcggadigtamakdervnll
sftgstqvgkqvglmvqerfgrsllelggnnaiiafedadlslvvpsalfaavgtagqrc
ttarrlfihesihdevvnrlkkayaqirvgnpwdpnvlygplhtkqavsmflgaveeakk
eggtvvyggkvmdrpgnyveptivtglghdasiahtetfapilyvfkfkneeevfawnne
vkqglsssiftkdlgrifrwlgpkgsdcgivnvniptsgaeiggafggekhtgggresgs
dawkqymrrstctinyskdlplaqgikfq