PDB entry 6o3g

View 6o3g on RCSB PDB site
Description: crystal structure of the fab fragment of the human hiv-1 neutralizing antibody pgzl1 in complex with its mper peptide epitope (region 671- 683 of hiv-1 gp41).
Deposited on 2019-02-26, released 2019-12-04
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 3.65 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: PGZL1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-End)
  • Chain 'B':
    Compound: PGZL1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-End)
  • Chain 'C':
    Compound: PGZL1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-226)
  • Chain 'D':
    Compound: PGZL1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-End)
  • Chain 'E':
    Compound: PGZL1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-226)
  • Chain 'F':
    Compound: PGZL1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-End)
  • Chain 'G':
    Compound: MEPER peptide, region 671-683 of HIV-1 gp41
    Species: Human immunodeficiency virus 1, synthetic [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-15)
  • Chain 'H':
    Compound: PGZL1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-End)
  • Chain 'I':
    Compound: MEPER peptide, region 671-683 of HIV-1 gp41
    Species: Human immunodeficiency virus 1, synthetic [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-15)
  • Chain 'L':
    Compound: PGZL1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-End)
  • Chain 'Q':
    Compound: MEPER peptide, region 671-683 of HIV-1 gp41
    Species: Human immunodeficiency virus 1, synthetic [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-15)
  • Chain 'S':
    Compound: MEPER peptide, region 671-683 of HIV-1 gp41
    Species: Human immunodeficiency virus 1, synthetic [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3G (0-15)
  • Heterogens: GOL, SO4

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6o3gA (A:)
evqlvqsggevkrpgssvtvsckatggtfstlafnwvrqapgqgpewmggivplfsivny
gqkfqgrltiradkstttvfldlsgltsadtatyycaregegwfgkplrafefwgqgtvi
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records):
    >6o3gA (A:)
evqlvqsggevkrpgssvtvsckatggtfstlafnwvrqapgqgpewmggivplfsivny
gqkfqgrltiradkstttvfldlsgltsadtatyycaregegwfgkplrafefwgqgtvi
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6o3gB (B:)
dvvmtqspgtlslspgeratlscrasqsvsggalawyqqkpgqaprlliydtssrptgvp
grfsgsgsgtdfsltisrlepedfavyycqqygtsqstfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6o3gB (B:)
dvvmtqspgtlslspgeratlscrasqsvsggalawyqqkpgqaprlliydtssrptgvp
grfsgsgsgtdfsltisrlepedfavyycqqygtsqstfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6o3gC (C:)
evqlvqsggevkrpgssvtvsckatggtfstlafnwvrqapgqgpewmggivplfsivny
gqkfqgrltiradkstttvfldlsgltsadtatyycaregegwfgkplrafefwgqgtvi
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6o3gD (D:)
dvvmtqspgtlslspgeratlscrasqsvsggalawyqqkpgqaprlliydtssrptgvp
grfsgsgsgtdfsltisrlepedfavyycqqygtsqstfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6o3gD (D:)
dvvmtqspgtlslspgeratlscrasqsvsggalawyqqkpgqaprlliydtssrptgvp
grfsgsgsgtdfsltisrlepedfavyycqqygtsqstfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >6o3gE (E:)
evqlvqsggevkrpgssvtvsckatggtfstlafnwvrqapgqgpewmggivplfsivny
gqkfqgrltiradkstttvfldlsgltsadtatyycaregegwfgkplrafefwgqgtvi
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6o3gF (F:)
dvvmtqspgtlslspgeratlscrasqsvsggalawyqqkpgqaprlliydtssrptgvp
grfsgsgsgtdfsltisrlepedfavyycqqygtsqstfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6o3gF (F:)
dvvmtqspgtlslspgeratlscrasqsvsggalawyqqkpgqaprlliydtssrptgvp
grfsgsgsgtdfsltisrlepedfavyycqqygtsqstfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalsqesvteqdskdstyslsstltlsk
adyekhkvyacevthqglsspvtksfnrge

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records:
    >6o3gG (G:)
nwfditnwlwyikkkk

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6o3gH (H:)
evqlvqsggevkrpgssvtvsckatggtfstlafnwvrqapgqgpewmggivplfsivny
gqkfqgrltiradkstttvfldlsgltsadtatyycaregegwfgkplrafefwgqgtvi
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records):
    >6o3gH (H:)
evqlvqsggevkrpgssvtvsckatggtfstlafnwvrqapgqgpewmggivplfsivny
gqkfqgrltiradkstttvfldlsgltsadtatyycaregegwfgkplrafefwgqgtvi
tvssastkgpsvfplapssksttaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records:
    >6o3gI (I:)
nwfditnwlwyikkkk

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6o3gL (L:)
dvvmtqspgtlslspgeratlscrasqsvsggalawyqqkpgqaprlliydtssrptgvp
grfsgsgsgtdfsltisrlepedfavyycqqygtsqstfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6o3gL (L:)
dvvmtqspgtlslspgeratlscrasqsvsggalawyqqkpgqaprlliydtssrptgvp
grfsgsgsgtdfsltisrlepedfavyycqqygtsqstfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records:
    >6o3gQ (Q:)
nwfditnwlwyikkkk

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records:
    >6o3gS (S:)
nwfditnwlwyikkkk