PDB entry 6o3c

View 6o3c on RCSB PDB site
Description: crystal structure of active smoothened bound to sag21k, cholesterol, and nbsmo8
Deposited on 2019-02-26, released 2019-07-03
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Smoothened homolog
    Species: Mus musculus [TaxId:10090]
    Gene: SMO, SMOH
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: NbSmo8
    Species: Lama glama, synthetic [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6O3C (0-End)
  • Heterogens: PO4, NA, OLB, NAG, LKD, CLR, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6o3cA (A:)
dykddddagsenlyfqgsgsprllshcgraahceplrynvclgsalpygatttllagdsd
sqeeahgklvlwsglrnaprcwaviqpllcavympkcendrvelpsrtlcqatrgpcaiv
erergwpdflrctpdhfpegcpnevqnikfnssgqceaplvrtdnpkswyedvegcgiqc
qnplfteaehqdmhsyiaafgavtglctlftlatfvadwrnsnrypavilfyvnacffvg
sigwlaqfmdgarreivcradgtmrfgeptssetlscviifvivyyalmagvvwfvvlty
awhtsfkalgttyqplsgktsyfhlltwslpfvltvailavaqvdgdsvsgicfvgykny
ryragfvlapiglvlivggyflirgvmtlfsiksnhpgllsekaaskinetmlrlgifgf
lafgfvlitfschfydffnqaewersfrdyvlcqanvtiglptkkpipdceiknrpsllv
ekinlfamfgtgiamstwvwtkatlliwrrtwcrltghsddepkr

    Sequence, based on observed residues (ATOM records):
    >6o3cA (A:)
lshcgraahceplrynvclgsalpygatttllagdsdsqeeahgklvlwsglrnaprcwa
viqpllcavympkcendrvelpsrtlcqatrgpcaiverergwpdflrctpdhfpegcpn
evqnikfnssgqceaplvrtdnpkswyedvegcgiqcqnplfteaehqdmhsyiaafgav
tglctlftlatfvadwrnsnrypavilfyvnacffvgsigwlaqfmdgarreivcradgt
mrfgeptssetlscviifvivyyalmagvvwfvvltyawhtsfkalgttyqplsgktsyf
hlltwslpfvltvailavaqvdgdsvsgicfvgyknyryragfvlapiglvlivggyfli
rgvmtlfsiksnhpgllsekaaskinetmlrlgifgflafgfvlitfschfydffnqaew
ersfrdyvlcqanvtigdceiknrpsllvekinlfamfgtgiamstwvwtkatlliwrrt
wcrl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6o3cB (B:)
qvqlqesggglvqaggslrlscaasgyifssyamgwyrqapgkerefvatigwgtityya
dsvkgrftisrdnakntvylqmnslkpedtavyycaaqdllyysfpgdhaywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6o3cB (B:)
qvqlqesggglvqaggslrlscaasgyifssyamgwyrqapgkerefvatigwgtityya
dsvkgrftisrdnakntvylqmnslkpedtavyycaaqdllyysfpgdhaywgqgtqvtv
ss